1 Ocak 2020 Dergi makalesi Açık Erişim

Balcioglu, Bertan Koray; Oncu, Melis Denizci; Ozturk, Hasan Umit; Yucel, Fatima; Kaya, Filiz; Serhatli, Muge; Polat, Hivda Ulbegi; Tekin, Saban; Bahadir, Aylin Ozdemir

Citation Style Language JSON

{
  "DOI": "10.3906/biy-2005-91", 
  "abstract": "In December 2019 a novel coronavirus was detected in Wuhan City of Hubei Province-China. Owing to a high rate of transmission from human to human, the new virus called SARS-CoV-2 differed from others by its unexpectedly rapid spread. The World Health Organization (WHO) described the most recent coronavirus epidemic as a global pandemic in March 2020. The virus spread triggered a health crisis (the COVID-19 disease) within three months, with socioeconomic implications. No approved targeted-therapies are available for COVID-19, yet. However, it is foreseen that antibody-based treatments may provide an immediate cure for patients. Current neutralizing antibody development studies primarily target the S protein among the structural elements of SARS-CoV-2, which mediates the cell entry of the virus through the angiotensin converting enzyme 2 (ACE2) receptor of host cells. This review aims to provide some of the neutralizing antibody development strategies for SARS-CoV-2 and in vitro and in vivo neutralization assays.", 
  "author": [
    {
      "family": "Balcioglu", 
      "given": " Bertan Koray"
    }, 
    {
      "family": "Oncu", 
      "given": " Melis Denizci"
    }, 
    {
      "family": "Ozturk", 
      "given": " Hasan Umit"
    }, 
    {
      "family": "Yucel", 
      "given": " Fatima"
    }, 
    {
      "family": "Kaya", 
      "given": " Filiz"
    }, 
    {
      "family": "Serhatli", 
      "given": " Muge"
    }, 
    {
      "family": "Polat", 
      "given": " Hivda Ulbegi"
    }, 
    {
      "family": "Tekin", 
      "given": " Saban"
    }, 
    {
      "family": "Bahadir", 
      "given": " Aylin Ozdemir"
    }
  ], 
  "container_title": "TURKISH JOURNAL OF BIOLOGY", 
  "id": "89241", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "page": "203-214", 
  "title": "SARS-CoV-2 neutralizing antibody development strategies", 
  "type": "article-journal", 
  "volume": "44"
}