1 Ocak 2020 Dergi makalesi Açık Erişim

Demir, Semsi Betul; Secinti, Hatice; Celebioglu, Neslihan; Ozdal, Murat; Sezen, Alev; Gulmez, Ozlem; Algur, Omer Faruk; Secen, Hasan

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Demir, Semsi Betul</dc:creator>
  <dc:creator>Secinti, Hatice</dc:creator>
  <dc:creator>Celebioglu, Neslihan</dc:creator>
  <dc:creator>Ozdal, Murat</dc:creator>
  <dc:creator>Sezen, Alev</dc:creator>
  <dc:creator>Gulmez, Ozlem</dc:creator>
  <dc:creator>Algur, Omer Faruk</dc:creator>
  <dc:creator>Secen, Hasan</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>Four linear nonphenolic diarylheptanoids were synthesized and their antibacterial activities were studied. (S)-2-Me-CBS-catalysed reduction of alnustone with BH3.SMe2 gave (R) (-)(4E,6E)-1,7-diphenylhepta-4,6-dien-3-ol, a natural product. Reduction of alnustone with Na in t-BuOH at -15 degrees C under NH3 atm gave ( E)-1,7-diphenylhept-5-en-3-one as a Birch-type reduction product. t-BuOK catalysed condensation of benzalacetone with propionyl chloride gave (4Z,6E)-5-hydroxy-1,7-diphenylhepta-4,6-dien-3-one, a natural product. (1E,4Z,6E)-5-Hydroxy-4-phenethyl-1,7-diphenylhepta-1,4,6-trien-3-one, a curcuminoid, was synthesized starting from pentan-2,4-dione in 3 steps. The synthesized chemical compounds were applied against 2 gram-positive bacteria (Bacillus cereus and Arthrobacter agilis), 4 gram-negative bacteria (Pseudomonas aeruginosa, Xanthomonas campestris, Klebsiella oxytoca, and Helicobacter pylori), and 1 yeast (Candida albicans) by the disc diffusion method. All of the synthesized compound exhibited different degrees of antimicrobial activity at concentrations between 20-100 mu g/disc against the test organisms.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/8221</dc:identifier>
  <dc:identifier>oai:zenodo.org:8221</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>TURKISH JOURNAL OF CHEMISTRY 44(3) 589-601</dc:source>
  <dc:title>Syntheses and antibacterial activities of 4 linear nonphenolic diarylheptanoids</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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