1 Ocak 2020 Dergi makalesi Açık Erişim

Demir, Semsi Betul; Secinti, Hatice; Celebioglu, Neslihan; Ozdal, Murat; Sezen, Alev; Gulmez, Ozlem; Algur, Omer Faruk; Secen, Hasan

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{
  "DOI": "10.3906/kim-1911-61", 
  "abstract": "Four linear nonphenolic diarylheptanoids were synthesized and their antibacterial activities were studied. (S)-2-Me-CBS-catalysed reduction of alnustone with BH3.SMe2 gave (R) (-)(4E,6E)-1,7-diphenylhepta-4,6-dien-3-ol, a natural product. Reduction of alnustone with Na in t-BuOH at -15 degrees C under NH3 atm gave ( E)-1,7-diphenylhept-5-en-3-one as a Birch-type reduction product. t-BuOK catalysed condensation of benzalacetone with propionyl chloride gave (4Z,6E)-5-hydroxy-1,7-diphenylhepta-4,6-dien-3-one, a natural product. (1E,4Z,6E)-5-Hydroxy-4-phenethyl-1,7-diphenylhepta-1,4,6-trien-3-one, a curcuminoid, was synthesized starting from pentan-2,4-dione in 3 steps. The synthesized chemical compounds were applied against 2 gram-positive bacteria (Bacillus cereus and Arthrobacter agilis), 4 gram-negative bacteria (Pseudomonas aeruginosa, Xanthomonas campestris, Klebsiella oxytoca, and Helicobacter pylori), and 1 yeast (Candida albicans) by the disc diffusion method. All of the synthesized compound exhibited different degrees of antimicrobial activity at concentrations between 20-100 mu g/disc against the test organisms.", 
  "author": [
    {
      "family": "Demir", 
      "given": " Semsi Betul"
    }, 
    {
      "family": "Secinti", 
      "given": " Hatice"
    }, 
    {
      "family": "Celebioglu", 
      "given": " Neslihan"
    }, 
    {
      "family": "Ozdal", 
      "given": " Murat"
    }, 
    {
      "family": "Sezen", 
      "given": " Alev"
    }, 
    {
      "family": "Gulmez", 
      "given": " Ozlem"
    }, 
    {
      "family": "Algur", 
      "given": " Omer Faruk"
    }, 
    {
      "family": "Secen", 
      "given": " Hasan"
    }
  ], 
  "container_title": "TURKISH JOURNAL OF CHEMISTRY", 
  "id": "8221", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "page": "589-601", 
  "title": "Syntheses and antibacterial activities of 4 linear nonphenolic diarylheptanoids", 
  "type": "article-journal", 
  "volume": "44"
}