1 Ocak 2015 Dergi makalesi Açık Erişim

Varisli, Lokman; Ozturk, Bilge E.; Akyuz, Gencer K.; Korkmaz, Kemal S.

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  "@context": "https://schema.org/", 
  "@id": 80041, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Varisli, Lokman"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Bioengn, Canc Biol Lab, Fac Engn, Izmir, Turkey", 
      "name": "Ozturk, Bilge E."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Bioengn, Canc Biol Lab, Fac Engn, Izmir, Turkey", 
      "name": "Akyuz, Gencer K."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Bioengn, Canc Biol Lab, Fac Engn, Izmir, Turkey", 
      "name": "Korkmaz, Kemal S."
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "Previously, it has been reported that HN1 is involved in cytoplasmic retention and degradation of androgen receptor in an AKT dependent manner. As HN1 is a hormone inducible gene, and has been shown that it is upregulated in various cancers, we studied the importance of HN1 function in -catenin signaling in prostate cancer cell line, PC-3 and mammary cancer cell line MDA-MB231. Here, we demonstrated that HN1 physically associates with GSK3/-catenin destruction complex and abundantly localizes to cytoplasm, especially when the GSK3 is phosphorylated on S9 residue. Further, ectopic HN1 expression results an increase in the -catenin degradation leading to loss of E-cadherin interaction, concurrently contributing to actin re-organization, colony formation and migration in cancer cell lines. Thus, we report that HN1 is an essential factor for -catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. J. Cell. Biochem. 116: 170-178, 2015. (c) 2014 Wiley Periodicals, Inc.", 
  "headline": "HN1 Negatively Influences the beta-Catenin/E-Cadherin Interaction, and Contributes to Migration in Prostate Cells", 
  "identifier": 80041, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "HN1 Negatively Influences the beta-Catenin/E-Cadherin Interaction, and Contributes to Migration in Prostate Cells", 
  "url": "https://aperta.ulakbim.gov.tr/record/80041"
}