1 Ocak 2015 Dergi makalesi Açık Erişim

Varisli, Lokman; Ozturk, Bilge E.; Akyuz, Gencer K.; Korkmaz, Kemal S.

Citation Style Language JSON

{
  "DOI": "10.1002/jcb.24956", 
  "abstract": "Previously, it has been reported that HN1 is involved in cytoplasmic retention and degradation of androgen receptor in an AKT dependent manner. As HN1 is a hormone inducible gene, and has been shown that it is upregulated in various cancers, we studied the importance of HN1 function in -catenin signaling in prostate cancer cell line, PC-3 and mammary cancer cell line MDA-MB231. Here, we demonstrated that HN1 physically associates with GSK3/-catenin destruction complex and abundantly localizes to cytoplasm, especially when the GSK3 is phosphorylated on S9 residue. Further, ectopic HN1 expression results an increase in the -catenin degradation leading to loss of E-cadherin interaction, concurrently contributing to actin re-organization, colony formation and migration in cancer cell lines. Thus, we report that HN1 is an essential factor for -catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. J. Cell. Biochem. 116: 170-178, 2015. (c) 2014 Wiley Periodicals, Inc.", 
  "author": [
    {
      "family": "Varisli", 
      "given": " Lokman"
    }, 
    {
      "family": "Ozturk", 
      "given": " Bilge E."
    }, 
    {
      "family": "Akyuz", 
      "given": " Gencer K."
    }, 
    {
      "family": "Korkmaz", 
      "given": " Kemal S."
    }
  ], 
  "container_title": "JOURNAL OF CELLULAR BIOCHEMISTRY", 
  "id": "80041", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2015, 
        1, 
        1
      ]
    ]
  }, 
  "page": "170-178", 
  "title": "HN1 Negatively Influences the beta-Catenin/E-Cadherin Interaction, and Contributes to Migration in Prostate Cells", 
  "type": "article-journal", 
  "volume": "116"
}