1 Ocak 2015 Dergi makalesi Açık Erişim

Varisli, Lokman; Ozturk, Bilge E.; Akyuz, Gencer K.; Korkmaz, Kemal S.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/80041</identifier>
  <creators>
    <creator>
      <creatorName>Varisli, Lokman</creatorName>
      <givenName>Lokman</givenName>
      <familyName>Varisli</familyName>
    </creator>
    <creator>
      <creatorName>Ozturk, Bilge E.</creatorName>
      <givenName>Bilge E.</givenName>
      <familyName>Ozturk</familyName>
      <affiliation>Ege Univ, Dept Bioengn, Canc Biol Lab, Fac Engn, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akyuz, Gencer K.</creatorName>
      <givenName>Gencer K.</givenName>
      <familyName>Akyuz</familyName>
      <affiliation>Ege Univ, Dept Bioengn, Canc Biol Lab, Fac Engn, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Korkmaz, Kemal S.</creatorName>
      <givenName>Kemal S.</givenName>
      <familyName>Korkmaz</familyName>
      <affiliation>Ege Univ, Dept Bioengn, Canc Biol Lab, Fac Engn, Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Hn1 Negatively Influences The Beta-Catenin/E-Cadherin Interaction, And Contributes To Migration In Prostate Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/80041</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/jcb.24956</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Previously, it has been reported that HN1 is involved in cytoplasmic retention and degradation of androgen receptor in an AKT dependent manner. As HN1 is a hormone inducible gene, and has been shown that it is upregulated in various cancers, we studied the importance of HN1 function in -catenin signaling in prostate cancer cell line, PC-3 and mammary cancer cell line MDA-MB231. Here, we demonstrated that HN1 physically associates with GSK3/-catenin destruction complex and abundantly localizes to cytoplasm, especially when the GSK3 is phosphorylated on S9 residue. Further, ectopic HN1 expression results an increase in the -catenin degradation leading to loss of E-cadherin interaction, concurrently contributing to actin re-organization, colony formation and migration in cancer cell lines. Thus, we report that HN1 is an essential factor for -catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. J. Cell. Biochem. 116: 170-178, 2015. (c) 2014 Wiley Periodicals, Inc.</description>
  </descriptions>
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