1 Ocak 2015 Dergi makalesi Açık Erişim

Bingol, H. Betul; Altin, Ayse; Bal, Tugba; Agopcan-Cinar, Sesil; Kizilel, Seda; Avci, Duygu

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{
  "@context": "https://schema.org/", 
  "@id": 78891, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey", 
      "name": "Bingol, H. Betul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey", 
      "name": "Altin, Ayse"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Chem & Biol Engn, TR-34450 Istanbul, Turkey", 
      "name": "Bal, Tugba"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey", 
      "name": "Agopcan-Cinar, Sesil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Chem & Biol Engn, TR-34450 Istanbul, Turkey", 
      "name": "Kizilel, Seda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey", 
      "name": "Avci, Duygu"
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "Phosphorus-containing acidic monomers are able to interact with the inorganic phase of mineralized tissues such as enamel, dentin, and bone. From this perspective, three phosphonic acid-containing acrylamide monomers with different lengths of alkyl chains were synthesized to be used for both self-etching dental adhesives and mineralized hydrogel scaffolds. Monomers were synthesized by the reaction of -aminophosphonates (diethyl aminomethylphosphonate, diethyl 2-aminobutan-2-ylphosphonate, and diethyl 2-aminooctan-2-ylphosphonate) with acryloyl chloride followed by the hydrolysis of phosphonate groups by using trimethylsilyl bromide. The properties such as pH in the range of mild self-etching adhesives, hydrolytic stability, high rate of copolymerizations with 2-hydroxyethyl methacrylate (HEMA) and HEMA/glycerol dimethacrylate, giving high-molecular-weight polymers on thermal polymerization, and strong decalcification ability of hydroxyapatite make these monomers good candidates for self-etching adhesives, although no appreciable effect of the number and size of the -substituents was observed. Hydrogel scaffolds containing phosphonic acid groups were fabricated, characterized, and mineralized. Altogether, the results suggest that these phosphonic acid-containing monomers have suitable properties to be used in fabrication of biomaterials for both dental and bone tissue engineering applications. (c) 2015 Wiley Periodicals, Inc.", 
  "headline": "Synthesis and evaluation of new phosphonic acid-functionalized acrylamides with potential biomedical applications", 
  "identifier": 78891, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Synthesis and evaluation of new phosphonic acid-functionalized acrylamides with potential biomedical applications", 
  "url": "https://aperta.ulakbim.gov.tr/record/78891"
}