1 Ocak 2019 Dergi makalesi Açık Erişim

Kucuksayan, Hakan; Akgun, Sakir; Ozes, Osman Nidai; Alikanoglu, Arsenal Sezgin; Yildiz, Mustafa; Dal, Egemen; Akca, Hakan

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{
  "@context": "https://schema.org/", 
  "@id": 75021, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey", 
      "name": "Kucuksayan, Hakan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey", 
      "name": "Akgun, Sakir"
    }, 
    {
      "@type": "Person", 
      "affiliation": "ALTAY Biopharma, San Bruno, CA USA", 
      "name": "Ozes, Osman Nidai"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Antalya Training & Res Hosp, Pathol Dept, Antalya, Turkey", 
      "name": "Alikanoglu, Arsenal Sezgin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Antalya Training & Res Hosp, Med Oncol, Antalya, Turkey", 
      "name": "Yildiz, Mustafa"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Pamukkale Univ, Fac Med, Denizli, Turkey", 
      "name": "Dal, Egemen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey", 
      "name": "Akca, Hakan"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Transforming growth factor-beta (TGF-beta) pathway plays crucial roles during the carcinogenesis and metastasis. TGF-beta receptor 2 (TGFBR2) is a key molecule for the regulation of TGF-beta pathway and frequently downregulated or lost in several cancer types including non-small cell lung cancer (NSCLC), and TGF-beta pathway is often regulated by negative-feedback mechanisms, but little is known about the mechanism of TGFBR2 downregulation in NSCLC. Here, we found that the expression of miR-520e is upregulated in metastatic tumor tissues compared with non-metastatic ones, and its expression is inversely correlated with that of TGFBR2 in clinical samples. We also discovered that TGF-beta dramatically increased the expression of miR-520e, which targeted and downregulated TGFBR2, and the suppression of miR-520e significantly impaired TGF-beta-induced TGFBR2 downregulation. Chromatin immunoprecipitation-PCR experiments further showed that miR-520e is transcriptionally induced by SMAD2/3 in response to TGF-beta. Our findings reveal a novel negative-feedback mechanism in TGF-beta signaling and the expression level of miR-520e could be a predictive biomarker for NSCLC metastasis.", 
  "headline": "TGF-beta-SMAD-miR-520e axis regulates NSCLC metastasis through a TGFBR2-mediated negative-feedback loop", 
  "identifier": 75021, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "TGF-beta-SMAD-miR-520e axis regulates NSCLC metastasis through a TGFBR2-mediated negative-feedback loop", 
  "url": "https://aperta.ulakbim.gov.tr/record/75021"
}