1 Ocak 2019 Dergi makalesi Açık Erişim

Kucuksayan, Hakan; Akgun, Sakir; Ozes, Osman Nidai; Alikanoglu, Arsenal Sezgin; Yildiz, Mustafa; Dal, Egemen; Akca, Hakan

JSON

{
  "conceptrecid": "75020", 
  "created": "2021-03-16T04:19:27.753202+00:00", 
  "doi": "10.1093/carcin/bgy166", 
  "files": [
    {
      "bucket": "6b61b4e6-ec3e-4cd2-918c-871c48711189", 
      "checksum": "md5:654df15e4cde28b2bf92944af86b4044", 
      "key": "bib-ea5a5560-b14f-41f2-99a3-a4dce042a5de.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/6b61b4e6-ec3e-4cd2-918c-871c48711189/bib-ea5a5560-b14f-41f2-99a3-a4dce042a5de.txt"
      }, 
      "size": 228, 
      "type": "txt"
    }
  ], 
  "id": 75021, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1093/carcin/bgy166.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/6b61b4e6-ec3e-4cd2-918c-871c48711189", 
    "doi": "https://doi.org/10.1093/carcin/bgy166", 
    "html": "https://aperta.ulakbim.gov.tr/record/75021", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/75021", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/75021"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey", 
        "name": "Kucuksayan, Hakan"
      }, 
      {
        "affiliation": "Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey", 
        "name": "Akgun, Sakir"
      }, 
      {
        "affiliation": "ALTAY Biopharma, San Bruno, CA USA", 
        "name": "Ozes, Osman Nidai"
      }, 
      {
        "affiliation": "Antalya Training & Res Hosp, Pathol Dept, Antalya, Turkey", 
        "name": "Alikanoglu, Arsenal Sezgin"
      }, 
      {
        "affiliation": "Antalya Training & Res Hosp, Med Oncol, Antalya, Turkey", 
        "name": "Yildiz, Mustafa"
      }, 
      {
        "affiliation": "Pamukkale Univ, Fac Med, Denizli, Turkey", 
        "name": "Dal, Egemen"
      }, 
      {
        "affiliation": "Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey", 
        "name": "Akca, Hakan"
      }
    ], 
    "description": "Transforming growth factor-beta (TGF-beta) pathway plays crucial roles during the carcinogenesis and metastasis. TGF-beta receptor 2 (TGFBR2) is a key molecule for the regulation of TGF-beta pathway and frequently downregulated or lost in several cancer types including non-small cell lung cancer (NSCLC), and TGF-beta pathway is often regulated by negative-feedback mechanisms, but little is known about the mechanism of TGFBR2 downregulation in NSCLC. Here, we found that the expression of miR-520e is upregulated in metastatic tumor tissues compared with non-metastatic ones, and its expression is inversely correlated with that of TGFBR2 in clinical samples. We also discovered that TGF-beta dramatically increased the expression of miR-520e, which targeted and downregulated TGFBR2, and the suppression of miR-520e significantly impaired TGF-beta-induced TGFBR2 downregulation. Chromatin immunoprecipitation-PCR experiments further showed that miR-520e is transcriptionally induced by SMAD2/3 in response to TGF-beta. Our findings reveal a novel negative-feedback mechanism in TGF-beta signaling and the expression level of miR-520e could be a predictive biomarker for NSCLC metastasis.", 
    "doi": "10.1093/carcin/bgy166", 
    "has_grant": false, 
    "journal": {
      "issue": "5", 
      "pages": "695-705", 
      "title": "CARCINOGENESIS", 
      "volume": "40"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2019-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "75021"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "75020"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "TGF-beta-SMAD-miR-520e axis regulates NSCLC metastasis through a TGFBR2-mediated negative-feedback loop"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 11.0, 
    "unique_downloads": 10.0, 
    "unique_views": 49.0, 
    "version_downloads": 11.0, 
    "version_unique_downloads": 10.0, 
    "version_unique_views": 49.0, 
    "version_views": 51.0, 
    "version_volume": 2508.0, 
    "views": 51.0, 
    "volume": 2508.0
  }, 
  "updated": "2021-03-16T04:19:27.799790+00:00"
}