1 Ocak 2019 Dergi makalesi Açık Erişim

Kucuksayan, Hakan; Akgun, Sakir; Ozes, Osman Nidai; Alikanoglu, Arsenal Sezgin; Yildiz, Mustafa; Dal, Egemen; Akca, Hakan

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/75021</identifier>
  <creators>
    <creator>
      <creatorName>Kucuksayan, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Kucuksayan</familyName>
      <affiliation>Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akgun, Sakir</creatorName>
      <givenName>Sakir</givenName>
      <familyName>Akgun</familyName>
      <affiliation>Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozes, Osman Nidai</creatorName>
      <givenName>Osman Nidai</givenName>
      <familyName>Ozes</familyName>
      <affiliation>ALTAY Biopharma, San Bruno, CA USA</affiliation>
    </creator>
    <creator>
      <creatorName>Alikanoglu, Arsenal Sezgin</creatorName>
      <givenName>Arsenal Sezgin</givenName>
      <familyName>Alikanoglu</familyName>
      <affiliation>Antalya Training &amp; Res Hosp, Pathol Dept, Antalya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yildiz, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Yildiz</familyName>
      <affiliation>Antalya Training &amp; Res Hosp, Med Oncol, Antalya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dal, Egemen</creatorName>
      <givenName>Egemen</givenName>
      <familyName>Dal</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akca, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Akca</familyName>
      <affiliation>Pamukkale Univ, Sch Med, Med Biol Dept, Denizli, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Tgf-Beta-Smad-Mir-520E Axis Regulates Nsclc Metastasis Through A Tgfbr2-Mediated Negative-Feedback Loop</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/75021</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1093/carcin/bgy166</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Transforming growth factor-beta (TGF-beta) pathway plays crucial roles during the carcinogenesis and metastasis. TGF-beta receptor 2 (TGFBR2) is a key molecule for the regulation of TGF-beta pathway and frequently downregulated or lost in several cancer types including non-small cell lung cancer (NSCLC), and TGF-beta pathway is often regulated by negative-feedback mechanisms, but little is known about the mechanism of TGFBR2 downregulation in NSCLC. Here, we found that the expression of miR-520e is upregulated in metastatic tumor tissues compared with non-metastatic ones, and its expression is inversely correlated with that of TGFBR2 in clinical samples. We also discovered that TGF-beta dramatically increased the expression of miR-520e, which targeted and downregulated TGFBR2, and the suppression of miR-520e significantly impaired TGF-beta-induced TGFBR2 downregulation. Chromatin immunoprecipitation-PCR experiments further showed that miR-520e is transcriptionally induced by SMAD2/3 in response to TGF-beta. Our findings reveal a novel negative-feedback mechanism in TGF-beta signaling and the expression level of miR-520e could be a predictive biomarker for NSCLC metastasis.</description>
  </descriptions>
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