Dergi makalesi Açık Erişim

Serum choline and butyrylcholinesterase changes in response to endotoxin in calves receiving intravenous choline administration

2019    Inan, O. Eralp; Tvarijonaviciute, A.; Kocaturk, M.; Rubio, C. P.; Kasap, S.; Cansev, M.; Ceron, J. J.; Yilmaz, Z.; Ulus, I. H.

Endotoxemia treatment options are still of interest due to high mortality and choline treatment is one of them because of its role in the cholinergic anti-inflammatory pathway. This study investigated serum choline and butyrylcholinesterase (BChE) responses, and their correlations with inflammatory, oxidative stress and tissue damage biomarkers, including paraoxanase-1 (PON1), and clinical signs in calves with endotoxemia and the effect of choline treatment in these responses. Healthy calves (n = 20) were divided equally into 4 groups: Control (0.9% NaCl, iv), Choline (C; 1 mg/kg/iv,once), Lipopolysaccharide (LPS; 2 mu g/kg/iv,once) and LPS + C. Clinical and laboratory examinations were performed before and 0.5-48 h (hrs) after treatments.