1 Ocak 2019 Dergi makalesi Açık Erişim

Karadeniz, Eda; Zora, Metin

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    <subfield code="a">Synthesis of 1-Azaspiro[4.5]deca-1,3-dienes from N-Propargylic beta-Enaminones in Basic Medium</subfield>
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    <subfield code="a">A facile, efficient and unprecedented method for the synthesis of spiro-2H-pyrroles is reported. When reacted with 1-ethynylcyclohexylamine, a, ss-alkynic ketones produced cyclohexane-embedded Npropargylic ss-enaminones, which in the presence of cesium carbonate underwent nucleophilic cyclization to afford 1-azaspiro[ 4.5] deca-1,3diene derivatives in good to excellent yields. This cyclization was found to be general for a variety of cyclohexane-embedded N-propargylic ss enaminones and demonstrated good tolerance to a broad range of aliphatic, aromatic and heteroaromatic groups with electron-withdrawing and electron-donating substituents. The decoration of pyrrole compounds with a spiro framework may exhibit potential for the synthesis of molecules of pharmacological interest.</subfield>
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    <subfield code="u">Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey</subfield>
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