1 Ocak 2019 Dergi makalesi Açık Erişim

Karadeniz, Eda; Zora, Metin

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{
  "@context": "https://schema.org/", 
  "@id": 70543, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Karadeniz, Eda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Zora, Metin"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "A facile, efficient and unprecedented method for the synthesis of spiro-2H-pyrroles is reported. When reacted with 1-ethynylcyclohexylamine, a, ss-alkynic ketones produced cyclohexane-embedded Npropargylic ss-enaminones, which in the presence of cesium carbonate underwent nucleophilic cyclization to afford 1-azaspiro[ 4.5] deca-1,3diene derivatives in good to excellent yields. This cyclization was found to be general for a variety of cyclohexane-embedded N-propargylic ss enaminones and demonstrated good tolerance to a broad range of aliphatic, aromatic and heteroaromatic groups with electron-withdrawing and electron-donating substituents. The decoration of pyrrole compounds with a spiro framework may exhibit potential for the synthesis of molecules of pharmacological interest.", 
  "headline": "Synthesis of 1-Azaspiro[4.5]deca-1,3-dienes from N-Propargylic beta-Enaminones in Basic Medium", 
  "identifier": 70543, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Synthesis of 1-Azaspiro[4.5]deca-1,3-dienes from N-Propargylic beta-Enaminones in Basic Medium", 
  "url": "https://aperta.ulakbim.gov.tr/record/70543"
}