1 Ocak 2019 Dergi makalesi Açık Erişim

Karadeniz, Eda; Zora, Metin

Citation Style Language JSON

{
  "DOI": "10.1055/s-0037-1611723", 
  "abstract": "A facile, efficient and unprecedented method for the synthesis of spiro-2H-pyrroles is reported. When reacted with 1-ethynylcyclohexylamine, a, ss-alkynic ketones produced cyclohexane-embedded Npropargylic ss-enaminones, which in the presence of cesium carbonate underwent nucleophilic cyclization to afford 1-azaspiro[ 4.5] deca-1,3diene derivatives in good to excellent yields. This cyclization was found to be general for a variety of cyclohexane-embedded N-propargylic ss enaminones and demonstrated good tolerance to a broad range of aliphatic, aromatic and heteroaromatic groups with electron-withdrawing and electron-donating substituents. The decoration of pyrrole compounds with a spiro framework may exhibit potential for the synthesis of molecules of pharmacological interest.", 
  "author": [
    {
      "family": "Karadeniz", 
      "given": " Eda"
    }, 
    {
      "family": "Zora", 
      "given": " Metin"
    }
  ], 
  "container_title": "SYNTHESIS-STUTTGART", 
  "id": "70543", 
  "issue": "10", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "2157-2170", 
  "title": "Synthesis of 1-Azaspiro[4.5]deca-1,3-dienes from N-Propargylic beta-Enaminones in Basic Medium", 
  "type": "article-journal", 
  "volume": "51"
}