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Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization

Ekineker, Guelcin; Nguyen, Christophe; Bayir, Suemeyra; Dominguez Gil, Sofia; Isci, Umit; Daurat, Morgane; Godefroy, Anastasia; Raehm, Laurence; Charnay, Clarence; Oliviero, Erwan; Ahsen, Vefa; Gary-Bobo, Magali; Durand, Jean-Olivier; Dumoulin, Fabienne


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  "@context": "https://schema.org/", 
  "@id": 67455, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey", 
      "name": "Ekineker, Guelcin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, 15 Ave Charles Flahault, F-34093 Montpellier 05, France", 
      "name": "Nguyen, Christophe"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey", 
      "name": "Bayir, Suemeyra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France", 
      "name": "Dominguez Gil, Sofia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey", 
      "name": "Isci, Umit"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, 15 Ave Charles Flahault, F-34093 Montpellier 05, France", 
      "name": "Daurat, Morgane"
    }, 
    {
      "@type": "Person", 
      "name": "Godefroy, Anastasia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France", 
      "name": "Raehm, Laurence"
    }, 
    {
      "@type": "Person", 
      "affiliation": "CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France", 
      "name": "Charnay, Clarence"
    }, 
    {
      "@type": "Person", 
      "affiliation": "CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France", 
      "name": "Oliviero, Erwan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey", 
      "name": "Ahsen, Vefa"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, 15 Ave Charles Flahault, F-34093 Montpellier 05, France", 
      "name": "Gary-Bobo, Magali"
    }, 
    {
      "@type": "Person", 
      "affiliation": "CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France", 
      "name": "Durand, Jean-Olivier"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey", 
      "name": "Dumoulin, Fabienne"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.", 
  "headline": "Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization", 
  "identifier": 67455, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization", 
  "url": "https://aperta.ulakbim.gov.tr/record/67455"
}
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