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Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds

Norris, Sean; Warner, Caroline C.; Thooft, Andrea M.; Demirci, Selin K.; Lampkin, Bryan J.; Miner, Kyle; Ellern, Arkady; VanVeller, Brett


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        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
        "name": "Norris, Sean"
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        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
        "name": "Warner, Caroline C."
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        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
        "name": "Thooft, Andrea M."
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      {
        "name": "Demirci, Selin K."
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      {
        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
        "name": "Lampkin, Bryan J."
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      {
        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
        "name": "Miner, Kyle"
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      {
        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
        "name": "Ellern, Arkady"
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        "affiliation": "Iowa State Univ, Dept Chem, Ames, IA 50011 USA", 
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    "description": "An unexpected nucleophilic aromatic substitution lead to a novel benzothiadiazole scaffold that bore the functional group pattern associated with benzyl-type photocleavable protecting groups. The new molecules display efficient photochemical release of leaving groups with blue light. The performance of both ortho- and meta-substituted derivatives was probed through both structural manipulation and computational metrics to improve performance.", 
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