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Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds

Norris, Sean; Warner, Caroline C.; Thooft, Andrea M.; Demirci, Selin K.; Lampkin, Bryan J.; Miner, Kyle; Ellern, Arkady; VanVeller, Brett


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/6579</identifier>
  <creators>
    <creator>
      <creatorName>Norris, Sean</creatorName>
      <givenName>Sean</givenName>
      <familyName>Norris</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Warner, Caroline C.</creatorName>
      <givenName>Caroline C.</givenName>
      <familyName>Warner</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Thooft, Andrea M.</creatorName>
      <givenName>Andrea M.</givenName>
      <familyName>Thooft</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Demirci, Selin K.</creatorName>
      <givenName>Selin K.</givenName>
      <familyName>Demirci</familyName>
    </creator>
    <creator>
      <creatorName>Lampkin, Bryan J.</creatorName>
      <givenName>Bryan J.</givenName>
      <familyName>Lampkin</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Miner, Kyle</creatorName>
      <givenName>Kyle</givenName>
      <familyName>Miner</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Ellern, Arkady</creatorName>
      <givenName>Arkady</givenName>
      <familyName>Ellern</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
    <creator>
      <creatorName>VanVeller, Brett</creatorName>
      <givenName>Brett</givenName>
      <familyName>VanVeller</familyName>
      <affiliation>Iowa State Univ, Dept Chem, Ames, IA 50011 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Blue-Light Photocleavable Protecting Groups Based On Benzothiadiazole Scaffolds</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/6579</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acs.orglett.9b04268</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">An unexpected nucleophilic aromatic substitution lead to a novel benzothiadiazole scaffold that bore the functional group pattern associated with benzyl-type photocleavable protecting groups. The new molecules display efficient photochemical release of leaving groups with blue light. The performance of both ortho- and meta-substituted derivatives was probed through both structural manipulation and computational metrics to improve performance.</description>
  </descriptions>
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