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Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds

Norris, Sean; Warner, Caroline C.; Thooft, Andrea M.; Demirci, Selin K.; Lampkin, Bryan J.; Miner, Kyle; Ellern, Arkady; VanVeller, Brett


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{
  "DOI": "10.1021/acs.orglett.9b04268", 
  "abstract": "An unexpected nucleophilic aromatic substitution lead to a novel benzothiadiazole scaffold that bore the functional group pattern associated with benzyl-type photocleavable protecting groups. The new molecules display efficient photochemical release of leaving groups with blue light. The performance of both ortho- and meta-substituted derivatives was probed through both structural manipulation and computational metrics to improve performance.", 
  "author": [
    {
      "family": "Norris", 
      "given": " Sean"
    }, 
    {
      "family": "Warner", 
      "given": " Caroline C."
    }, 
    {
      "family": "Thooft", 
      "given": " Andrea M."
    }, 
    {
      "family": "Demirci", 
      "given": " Selin K."
    }, 
    {
      "family": "Lampkin", 
      "given": " Bryan J."
    }, 
    {
      "family": "Miner", 
      "given": " Kyle"
    }, 
    {
      "family": "Ellern", 
      "given": " Arkady"
    }, 
    {
      "family": "VanVeller", 
      "given": " Brett"
    }
  ], 
  "container_title": "ORGANIC LETTERS", 
  "id": "6579", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2020, 
        1, 
        1
      ]
    ]
  }, 
  "page": "270-273", 
  "title": "Blue-Light Photocleavable Protecting Groups Based on Benzothiadiazole Scaffolds", 
  "type": "article-journal", 
  "volume": "22"
}
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