1 Ocak 2014 Dergi makalesi Açık Erişim

Sari, A. Nihal; Kacan, Meltem; Unsal, Demet; Firat, Seyhan Sahan; Buharalioglu, C. Kemel; Vezir, Ozden; Korkmaz, Belma; Cuez, Tuba; Canacankatan, Necmiye; Sucu, Nehir; Ayaz, Lokman; Gumus, Lulufer Tamer; Gorur, Aysegul; Tunctan, Bahar

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/65705</identifier>
  <creators>
    <creator>
      <creatorName>Sari, A. Nihal</creatorName>
      <givenName>A. Nihal</givenName>
      <familyName>Sari</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kacan, Meltem</creatorName>
      <givenName>Meltem</givenName>
      <familyName>Kacan</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Unsal, Demet</creatorName>
      <givenName>Demet</givenName>
      <familyName>Unsal</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Firat, Seyhan Sahan</creatorName>
      <givenName>Seyhan Sahan</givenName>
      <familyName>Firat</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Buharalioglu, C. Kemel</creatorName>
      <givenName>C. Kemel</givenName>
      <familyName>Buharalioglu</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Vezir, Ozden</creatorName>
      <givenName>Ozden</givenName>
      <familyName>Vezir</familyName>
      <affiliation>Mersin Univ, Fac Med, Dept Cardiovasc Surg, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Korkmaz, Belma</creatorName>
      <givenName>Belma</givenName>
      <familyName>Korkmaz</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cuez, Tuba</creatorName>
      <givenName>Tuba</givenName>
      <familyName>Cuez</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Canacankatan, Necmiye</creatorName>
      <givenName>Necmiye</givenName>
      <familyName>Canacankatan</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Biochem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sucu, Nehir</creatorName>
      <givenName>Nehir</givenName>
      <familyName>Sucu</familyName>
      <affiliation>Mersin Univ, Fac Med, Dept Cardiovasc Surg, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ayaz, Lokman</creatorName>
      <givenName>Lokman</givenName>
      <familyName>Ayaz</familyName>
      <affiliation>Mersin Univ, Fac Med, Dept Med Biochem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gumus, Lulufer Tamer</creatorName>
      <givenName>Lulufer Tamer</givenName>
      <familyName>Gumus</familyName>
      <affiliation>Mersin Univ, Fac Med, Dept Med Biochem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gorur, Aysegul</creatorName>
      <givenName>Aysegul</givenName>
      <familyName>Gorur</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Biochem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tunctan, Bahar</creatorName>
      <givenName>Bahar</givenName>
      <familyName>Tunctan</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmacol, TR-33169 Mersin, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Contribution Of Rhoa/Rho-Kinase/Mek1/Erk1/2/Inos Pathway To Ischemia/Reperfusion-Induced Oxidative/Nitrosative Stress And Inflammation Leading To Distant And Target Organ Injury In Rats</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/65705</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejphar.2013.11.027</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The small G protein RhoA and its downstream effector Rho-kinase play an important role in various physiopathological processes including ischemia/reperfusion (I/R) injury. Reactive oxygen and nitrogen species produced by iNOS and NADPH oxidase are important mediators of inflammation and organ injury following an initial localized I/R event. The aim of this study was to determine whether RhoA/Rho-kinase signaling pathway increases the expression and activity of MEK1, ERK1/2, iNOS, gp91(phox), and p47(phox), and peroxynitrite formation which result in oxidative/nitrosative stress and inflammation leading to hindlimb PR-induced injury in kidney as a distant organ and;,gastrocnemius muscle as a target organ. I/R-induced distant and target organ injury was performed by using the rat hindlimb tourniquet model, I/R caused an increase in the expression and/or activity of RhoA, MEK1, ERK1/2, iNOS, gp91(phox), p47(phox), and 3-nitrotyrosine and nitrotyrosine levels in the tissues. Although Rho-kinase activity was increased by I/R in the kidney, its activity was decreased in the muscle. Serum and tissue MDA levels and MPO activity were increased following I/R. PR also caused an increase in SOD and catalase activities associated with decreased GSH levels in the tissues. Y-27632, a selective Rho-kinase inhibitor, (100 mu g/kg, i.p.; 1 h before reperfusion) prevented the I/R-induced changes except Rho-kinase activity in the muscle. These results suggest that activation of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway associated with oxidative/nitrosative stress and inflammation contributes to hindlimb PR-induced distant organ injury in rats. It also seems that hindlimb I/R induces target organ injury via upregulation of RhoA/MEK1/ERK1/2/iNOS pathway associated with decreased Rho-kinase activity. (C) 2013 Elsevier B.V. All rights reserved.</description>
  </descriptions>
</resource>