1 Ocak 2014 Dergi makalesi Açık Erişim

Marton, Annamaria; Kolozsi, Csongor; Kusz, Erzsebet; Olah, Zoltan; Letoha, Tamas; Vizler, Csaba; Pecze, Laszlo

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Marton, Annamaria</dc:creator>
  <dc:creator>Kolozsi, Csongor</dc:creator>
  <dc:creator>Kusz, Erzsebet</dc:creator>
  <dc:creator>Olah, Zoltan</dc:creator>
  <dc:creator>Letoha, Tamas</dc:creator>
  <dc:creator>Vizler, Csaba</dc:creator>
  <dc:creator>Pecze, Laszlo</dc:creator>
  <dc:date>2014-01-01</dc:date>
  <dc:description>Background: Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: To evaluate the effect of PG in sepsis induced by the bacterial endotoxin lipopolysaccharide (LPS). Methods: Balb/c mice were treated with LPS (1 mg/kg b. w., i. p.) with or without PG (5 g/kg b. w. i. v.). The survival rate and the production of inflammatory cytokines were measured. In RAW264.7 mouse macrophages encoding NF-kappa B-luc reporter gene, the nuclear transcription factor kappaB (NF-kappa B) activation was measured. Results: We found that intravenous PG increased the mortality rate in sepsis induced by the bacterial endotoxin lipopolysaccharide (LPS) in mice. In accordance with that, PG enhanced LPS-induced production of inflammatory cytokines, including tumor necrosis factor-a (TNF-alpha) and interleukin-6 (IL-6) in vivo. PG also increased the LPS-induced macrophage activation in vitro as detected by measuring NF-kappa B activation. Conclusion: Our results indicate that drugs containing high doses of PG can pose a risk when administered to patients suffering from or prone to Gram negative bacterial infection.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/65285</dc:identifier>
  <dc:identifier>oai:zenodo.org:65285</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>IRANIAN JOURNAL OF IMMUNOLOGY 11(2) 113-122</dc:source>
  <dc:title>Propylene-Glycol Aggravates LPS-Induced Sepsis through Production of TNF-alpha and IL-6</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>