1 Ocak 2014 Dergi makalesi Açık Erişim

Marton, Annamaria; Kolozsi, Csongor; Kusz, Erzsebet; Olah, Zoltan; Letoha, Tamas; Vizler, Csaba; Pecze, Laszlo

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/65285</identifier>
  <creators>
    <creator>
      <creatorName>Marton, Annamaria</creatorName>
      <givenName>Annamaria</givenName>
      <familyName>Marton</familyName>
      <affiliation>Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Kolozsi, Csongor</creatorName>
      <givenName>Csongor</givenName>
      <familyName>Kolozsi</familyName>
      <affiliation>Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Kusz, Erzsebet</creatorName>
      <givenName>Erzsebet</givenName>
      <familyName>Kusz</familyName>
      <affiliation>Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Olah, Zoltan</creatorName>
      <givenName>Zoltan</givenName>
      <familyName>Olah</familyName>
    </creator>
    <creator>
      <creatorName>Letoha, Tamas</creatorName>
      <givenName>Tamas</givenName>
      <familyName>Letoha</familyName>
    </creator>
    <creator>
      <creatorName>Vizler, Csaba</creatorName>
      <givenName>Csaba</givenName>
      <familyName>Vizler</familyName>
      <affiliation>Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Pecze, Laszlo</creatorName>
      <givenName>Laszlo</givenName>
      <familyName>Pecze</familyName>
    </creator>
  </creators>
  <titles>
    <title>Propylene-Glycol Aggravates Lps-Induced Sepsis Through Production Of Tnf-Alpha And Il-6</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/65285</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.81043/aperta.65284</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.81043/aperta.65285</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background: Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: To evaluate the effect of PG in sepsis induced by the bacterial endotoxin lipopolysaccharide (LPS). Methods: Balb/c mice were treated with LPS (1 mg/kg b. w., i. p.) with or without PG (5 g/kg b. w. i. v.). The survival rate and the production of inflammatory cytokines were measured. In RAW264.7 mouse macrophages encoding NF-kappa B-luc reporter gene, the nuclear transcription factor kappaB (NF-kappa B) activation was measured. Results: We found that intravenous PG increased the mortality rate in sepsis induced by the bacterial endotoxin lipopolysaccharide (LPS) in mice. In accordance with that, PG enhanced LPS-induced production of inflammatory cytokines, including tumor necrosis factor-a (TNF-alpha) and interleukin-6 (IL-6) in vivo. PG also increased the LPS-induced macrophage activation in vitro as detected by measuring NF-kappa B activation. Conclusion: Our results indicate that drugs containing high doses of PG can pose a risk when administered to patients suffering from or prone to Gram negative bacterial infection.</description>
  </descriptions>
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