1 Ocak 2014 Dergi makalesi Açık Erişim

Marton, Annamaria; Kolozsi, Csongor; Kusz, Erzsebet; Olah, Zoltan; Letoha, Tamas; Vizler, Csaba; Pecze, Laszlo

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{
  "URL": "https://aperta.ulakbim.gov.tr/record/65285", 
  "abstract": "Background: Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: To evaluate the effect of PG in sepsis induced by the bacterial endotoxin lipopolysaccharide (LPS). Methods: Balb/c mice were treated with LPS (1 mg/kg b. w., i. p.) with or without PG (5 g/kg b. w. i. v.). The survival rate and the production of inflammatory cytokines were measured. In RAW264.7 mouse macrophages encoding NF-kappa B-luc reporter gene, the nuclear transcription factor kappaB (NF-kappa B) activation was measured. Results: We found that intravenous PG increased the mortality rate in sepsis induced by the bacterial endotoxin lipopolysaccharide (LPS) in mice. In accordance with that, PG enhanced LPS-induced production of inflammatory cytokines, including tumor necrosis factor-a (TNF-alpha) and interleukin-6 (IL-6) in vivo. PG also increased the LPS-induced macrophage activation in vitro as detected by measuring NF-kappa B activation. Conclusion: Our results indicate that drugs containing high doses of PG can pose a risk when administered to patients suffering from or prone to Gram negative bacterial infection.", 
  "author": [
    {
      "family": "Marton", 
      "given": " Annamaria"
    }, 
    {
      "family": "Kolozsi", 
      "given": " Csongor"
    }, 
    {
      "family": "Kusz", 
      "given": " Erzsebet"
    }, 
    {
      "family": "Olah", 
      "given": " Zoltan"
    }, 
    {
      "family": "Letoha", 
      "given": " Tamas"
    }, 
    {
      "family": "Vizler", 
      "given": " Csaba"
    }, 
    {
      "family": "Pecze", 
      "given": " Laszlo"
    }
  ], 
  "container_title": "IRANIAN JOURNAL OF IMMUNOLOGY", 
  "id": "65285", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2014, 
        1, 
        1
      ]
    ]
  }, 
  "page": "113-122", 
  "title": "Propylene-Glycol Aggravates LPS-Induced Sepsis through Production of TNF-alpha and IL-6", 
  "type": "article-journal", 
  "volume": "11"
}