1 Ocak 2014 Dergi makalesi Açık Erişim

Babadagli, Mustafa Ege; Tezcan, Berna; Yilmaz, Seda Tasir; Tufan, A. Cevik

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/61247</identifier>
  <creators>
    <creator>
      <creatorName>Babadagli, Mustafa Ege</creatorName>
      <givenName>Mustafa Ege</givenName>
      <familyName>Babadagli</familyName>
    </creator>
    <creator>
      <creatorName>Tezcan, Berna</creatorName>
      <givenName>Berna</givenName>
      <familyName>Tezcan</familyName>
      <affiliation>Osmangazi Univ, Sch Med, Dept Histol &amp; Embryol, Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Seda Tasir</creatorName>
      <givenName>Seda Tasir</givenName>
      <familyName>Yilmaz</familyName>
      <affiliation>Ankara Univ, Inst Biotechnol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tufan, A. Cevik</creatorName>
      <givenName>A. Cevik</givenName>
      <familyName>Tufan</familyName>
      <affiliation>Pamukkale Univ, Sch Med, Dept Histol &amp; Embryol, Denizli, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Matrilin-3 As A Putative Effector Of C-Type Natriuretic Peptide Signaling During Tgf-Beta Induced Chondrogenic Differentiation Of Mesenchymal Stem Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/61247</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11033-014-3448-3</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">C-type natriuretic peptide (CNP) signaling has been implicated as an important regulator of chondrogenic differentiation during endochondral bone development. This preliminary study further investigated the putative effectors and/or targets of CNP signaling in transforming growth factor (TGF)-beta induced in vitro chondrogenic differentiation of mesenchymal stem cells (MSCs). Previously characterized human trabecular bone derived MSCs were induced either with only TGF-beta 1 or with a combination of TGF-beta 1 and CNP in micromass culture for 10 or 20 days. Genome wide gene expression profile changes in between these two groups were analyzed on day-10 or day-20 of culture. Results revealed that there were only 7 genes, whose expression change was fourfolds or higher in TGF-beta 1 and CNP fed group in comparison to only TGF-beta 1 fed group. The up-regulated genes included matrilin-3 (MATN3), engulfment and cell motility 1 (ELMO1), CD24, and DCN1, defective in cullin neddylation 1, domain containing 1 (DCUN1D1). The down-regulated genes, on the other hand, included LIM domain kinase 2 (LIMK2), Ewing sarcoma breakpoint region 1, and guanine nucleotide binding protein (G protein), gamma 12 (GNG12). The up-regulation of MATN3 was confirmed on the basis of RT-PCR. The known literature on both CNP signaling and MATN3 function in chondrogenesis match with each other and suggest MATN3 as a putative effector and/or target of CNP signaling during this process.</description>
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