1 Ocak 2020 Dergi makalesi Açık Erişim

Cevik, Mehtap; Gunduz, Meliha Koldemir; Deliorman, Gokce; Susleyici, Belgin

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{
  "@context": "https://schema.org/", 
  "@id": 6037, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Dept Mol Biol, Div Biol, Fac Arts & Sci, Istanbul, Turkey", 
      "name": "Cevik, Mehtap"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Kutahya Hlth Sci Univ, Dept Med Serv & Tech, Kutahya, Turkey", 
      "name": "Gunduz, Meliha Koldemir"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Beykoz Univ, Fac Engn & Architecture, Dept Software Engn, Istanbul, Turkey", 
      "name": "Deliorman, Gokce"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Dept Mol Biol, Div Biol, Fac Arts & Sci, Istanbul, Turkey", 
      "name": "Susleyici, Belgin"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were treated with different doses of linoleic acid, hydrogen peroxide and ethanol; and proliferation of the cells examined with real time monitoring iCELLingence system. Gene expression levels were measured by q-PCR. As a response to 24h 480 mu M linoleic acid treatment, Niban gene expression was found to be higher than control group (p = 0.008), whereas 24 h 90 mM ethanol treatment was determined to be lower than control group (p = 0.008). The highest value of Niban gene expression among H2O2 treatment groups was detected in 4h 600 mu M H2O2 in comparison to control group (p = 0.008). To understand role of Niban in adipogenesis, Niban gene expressions were compared between pre-adipocytes and advanced fat accumulated adipocytes and determined to be significantly different (p = 0.042). Our results suggest that Niban might be involved in stress response process in adipocytes. However, the exact molecular role of Niban needs to be investigated in further studies.", 
  "headline": "Alterations in niban gene expression as a response to stress conditions in 3T3-L1 adipocytes", 
  "identifier": 6037, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Alterations in niban gene expression as a response to stress conditions in 3T3-L1 adipocytes", 
  "url": "https://aperta.ulakbim.gov.tr/record/6037"
}