1 Ocak 2020 Dergi makalesi Açık Erişim

Cevik, Mehtap; Gunduz, Meliha Koldemir; Deliorman, Gokce; Susleyici, Belgin

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/6037</identifier>
  <creators>
    <creator>
      <creatorName>Cevik, Mehtap</creatorName>
      <givenName>Mehtap</givenName>
      <familyName>Cevik</familyName>
      <affiliation>Marmara Univ, Dept Mol Biol, Div Biol, Fac Arts &amp; Sci, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gunduz, Meliha Koldemir</creatorName>
      <givenName>Meliha Koldemir</givenName>
      <familyName>Gunduz</familyName>
      <affiliation>Kutahya Hlth Sci Univ, Dept Med Serv &amp; Tech, Kutahya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Deliorman, Gokce</creatorName>
      <givenName>Gokce</givenName>
      <familyName>Deliorman</familyName>
      <affiliation>Beykoz Univ, Fac Engn &amp; Architecture, Dept Software Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Susleyici, Belgin</creatorName>
      <givenName>Belgin</givenName>
      <familyName>Susleyici</familyName>
      <affiliation>Marmara Univ, Dept Mol Biol, Div Biol, Fac Arts &amp; Sci, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Alterations In Niban Gene Expression As A Response To Stress Conditions In 3T3-L1 Adipocytes</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/6037</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11033-020-05992-5</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were treated with different doses of linoleic acid, hydrogen peroxide and ethanol; and proliferation of the cells examined with real time monitoring iCELLingence system. Gene expression levels were measured by q-PCR. As a response to 24h 480 mu M linoleic acid treatment, Niban gene expression was found to be higher than control group (p = 0.008), whereas 24 h 90 mM ethanol treatment was determined to be lower than control group (p = 0.008). The highest value of Niban gene expression among H2O2 treatment groups was detected in 4h 600 mu M H2O2 in comparison to control group (p = 0.008). To understand role of Niban in adipogenesis, Niban gene expressions were compared between pre-adipocytes and advanced fat accumulated adipocytes and determined to be significantly different (p = 0.042). Our results suggest that Niban might be involved in stress response process in adipocytes. However, the exact molecular role of Niban needs to be investigated in further studies.</description>
  </descriptions>
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