1 Ocak 2016 Dergi makalesi Açık Erişim

Ocakoglu, Kasim; Er, Ozge; Ersoz, Onur Alp; Lambrecht, Fatma Yurt; Ince, Mine; Kayabasi, Cagla; Gunduz, Cumhur

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        "name": "Ocakoglu, Kasim"
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey", 
        "name": "Er, Ozge"
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey", 
        "name": "Ersoz, Onur Alp"
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey", 
        "name": "Lambrecht, Fatma Yurt"
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      {
        "affiliation": "Mersin Univ, Fac Technol, Dept Energy Syst Engn, TR-33480 Tarsus, Mersin, Turkey", 
        "name": "Ince, Mine"
      }, 
      {
        "affiliation": "Ege Univ, Fac Med, Dept Med Biol, TR-35100 Izmir, Turkey", 
        "name": "Kayabasi, Cagla"
      }, 
      {
        "affiliation": "Ege Univ, Fac Med, Dept Med Biol, TR-35100 Izmir, Turkey", 
        "name": "Gunduz, Cumhur"
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    "description": "Photodynamic therapy (PDT) is a medical treatment for the removal of target tissues involving the delivery of a photosensitizer agent followed by irradiation with visible light. In the present study, symmetric Zn(II)Pc 1 and asymmetrically substituted Zn(II)Pc 2 were synthesized and examined multifunctional agents for tumor nuclear imaging, and PDT potential. The Zn(II)Pc 1 and Zn(II)Pc 2 were radiolabeled with I-131 with high efficiency (93.4 +/- 1.6% and 91.4 +/- 1.6%, respectively). The results of the biodistribution study showed that radiolabeled Zn(II)Pc 1 had high uptake on lung, large intestine, ovary and pancreas. However, the uptake of radiolabeled Zn(II)Pc 2 was statically significant in pancreas and intestine. In PDT studies, EMT6/P (mouse mammary cell) and HeLa (cervical adenocarcinoma cell) with Zn(II)Pc 1 and Zn(II)Pc 2 were exposed to red light at the doses of 10-30 J/cm(2). Although PDT activity of Zn(II)Pc 2 in HeLa cell line was determined, Zn(II)Pc 1 showed no phototoxic effect in both cell lines. In conclusion, radiolabeled Zn(II)Pc 1 might be a promising imaging agent for the lung, the ovary pancreas, and the colon tumors. However, radiolabeled Zn(II)Pc 2 might be a promising nuclear imaging agent for the colon and the pancreas tumors and promising PDT agent for cervical tumors. (C) 2016 Elsevier B.V. All rights reserved.", 
    "doi": "10.1016/j.jddst.2016.04.005", 
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    "journal": {
      "pages": "164-169", 
      "title": "JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY", 
      "volume": "33"
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      "title": "Dergi makalesi", 
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    "title": "Evaluation of nuclear imaging potential and photodynamic therapy efficacy of symmetrical and asymmetrical zinc phthalocyanines"
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