1 Ocak 2016 Dergi makalesi Açık Erişim

Ocakoglu, Kasim; Er, Ozge; Ersoz, Onur Alp; Lambrecht, Fatma Yurt; Ince, Mine; Kayabasi, Cagla; Gunduz, Cumhur

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/59451</identifier>
  <creators>
    <creator>
      <creatorName>Ocakoglu, Kasim</creatorName>
      <givenName>Kasim</givenName>
      <familyName>Ocakoglu</familyName>
    </creator>
    <creator>
      <creatorName>Er, Ozge</creatorName>
      <givenName>Ozge</givenName>
      <familyName>Er</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ersoz, Onur Alp</creatorName>
      <givenName>Onur Alp</givenName>
      <familyName>Ersoz</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Lambrecht, Fatma Yurt</creatorName>
      <givenName>Fatma Yurt</givenName>
      <familyName>Lambrecht</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ince, Mine</creatorName>
      <givenName>Mine</givenName>
      <familyName>Ince</familyName>
      <affiliation>Mersin Univ, Fac Technol, Dept Energy Syst Engn, TR-33480 Tarsus, Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayabasi, Cagla</creatorName>
      <givenName>Cagla</givenName>
      <familyName>Kayabasi</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Med Biol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gunduz, Cumhur</creatorName>
      <givenName>Cumhur</givenName>
      <familyName>Gunduz</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Med Biol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Evaluation Of Nuclear Imaging Potential And Photodynamic Therapy Efficacy Of Symmetrical And Asymmetrical Zinc Phthalocyanines</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/59451</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jddst.2016.04.005</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Photodynamic therapy (PDT) is a medical treatment for the removal of target tissues involving the delivery of a photosensitizer agent followed by irradiation with visible light. In the present study, symmetric Zn(II)Pc 1 and asymmetrically substituted Zn(II)Pc 2 were synthesized and examined multifunctional agents for tumor nuclear imaging, and PDT potential. The Zn(II)Pc 1 and Zn(II)Pc 2 were radiolabeled with I-131 with high efficiency (93.4 +/- 1.6% and 91.4 +/- 1.6%, respectively). The results of the biodistribution study showed that radiolabeled Zn(II)Pc 1 had high uptake on lung, large intestine, ovary and pancreas. However, the uptake of radiolabeled Zn(II)Pc 2 was statically significant in pancreas and intestine. In PDT studies, EMT6/P (mouse mammary cell) and HeLa (cervical adenocarcinoma cell) with Zn(II)Pc 1 and Zn(II)Pc 2 were exposed to red light at the doses of 10-30 J/cm(2). Although PDT activity of Zn(II)Pc 2 in HeLa cell line was determined, Zn(II)Pc 1 showed no phototoxic effect in both cell lines. In conclusion, radiolabeled Zn(II)Pc 1 might be a promising imaging agent for the lung, the ovary pancreas, and the colon tumors. However, radiolabeled Zn(II)Pc 2 might be a promising nuclear imaging agent for the colon and the pancreas tumors and promising PDT agent for cervical tumors. (C) 2016 Elsevier B.V. All rights reserved.</description>
  </descriptions>
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