1 Ocak 2016 Dergi makalesi Açık Erişim

Ocakoglu, Kasim; Er, Ozge; Ersoz, Onur Alp; Lambrecht, Fatma Yurt; Ince, Mine; Kayabasi, Cagla; Gunduz, Cumhur

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{
  "DOI": "10.1016/j.jddst.2016.04.005", 
  "abstract": "Photodynamic therapy (PDT) is a medical treatment for the removal of target tissues involving the delivery of a photosensitizer agent followed by irradiation with visible light. In the present study, symmetric Zn(II)Pc 1 and asymmetrically substituted Zn(II)Pc 2 were synthesized and examined multifunctional agents for tumor nuclear imaging, and PDT potential. The Zn(II)Pc 1 and Zn(II)Pc 2 were radiolabeled with I-131 with high efficiency (93.4 +/- 1.6% and 91.4 +/- 1.6%, respectively). The results of the biodistribution study showed that radiolabeled Zn(II)Pc 1 had high uptake on lung, large intestine, ovary and pancreas. However, the uptake of radiolabeled Zn(II)Pc 2 was statically significant in pancreas and intestine. In PDT studies, EMT6/P (mouse mammary cell) and HeLa (cervical adenocarcinoma cell) with Zn(II)Pc 1 and Zn(II)Pc 2 were exposed to red light at the doses of 10-30 J/cm(2). Although PDT activity of Zn(II)Pc 2 in HeLa cell line was determined, Zn(II)Pc 1 showed no phototoxic effect in both cell lines. In conclusion, radiolabeled Zn(II)Pc 1 might be a promising imaging agent for the lung, the ovary pancreas, and the colon tumors. However, radiolabeled Zn(II)Pc 2 might be a promising nuclear imaging agent for the colon and the pancreas tumors and promising PDT agent for cervical tumors. (C) 2016 Elsevier B.V. All rights reserved.", 
  "author": [
    {
      "family": "Ocakoglu", 
      "given": " Kasim"
    }, 
    {
      "family": "Er", 
      "given": " Ozge"
    }, 
    {
      "family": "Ersoz", 
      "given": " Onur Alp"
    }, 
    {
      "family": "Lambrecht", 
      "given": " Fatma Yurt"
    }, 
    {
      "family": "Ince", 
      "given": " Mine"
    }, 
    {
      "family": "Kayabasi", 
      "given": " Cagla"
    }, 
    {
      "family": "Gunduz", 
      "given": " Cumhur"
    }
  ], 
  "container_title": "JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY", 
  "id": "59451", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "164-169", 
  "title": "Evaluation of nuclear imaging potential and photodynamic therapy efficacy of symmetrical and asymmetrical zinc phthalocyanines", 
  "type": "article-journal", 
  "volume": "33"
}