1 Ocak 2016 Dergi makalesi Açık Erişim

Akturk, Omer; Keskin, Dilek

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  <dc:creator>Akturk, Omer</dc:creator>
  <dc:creator>Keskin, Dilek</dc:creator>
  <dc:date>2016-01-01</dc:date>
  <dc:description>As a novel approach in skin tissue engineering, gold nanoparticles (AuNPs) were synthesized and incorporated at different concentrations into collagen/PEO nanofibrous matrices in this study. The group containing 14.27 ppm AuNPs (CM-Au) had the best nanofibrous morphology. CM-Au was cross-linked with glutaraldehyde vapor (CM-AuX). All groups were disrupted in collagenase in 2 h, but cross-linked groups and Matriderm (R) resisted hydrolytic degradation for 7 and 14 days, respectively. Due to its small pores and dense structure, lower water swelling results (7.26 +/- 2.62 g/g) were obtained for CM-AuX than Matriderm (17.51 +/- 1.97 g/g). CM-Au and Matriderm had statistically similar tensile strength and elastic modulus, but elongation at break of CM-Au (over 100%) was significantly better than that of Matriderm. After cross-linking, tensile strength and elastic modulus of collagen matrix was further improved. AuNPs (37 and 42 nm) seemed to be nontoxic on 3T3 fibroblasts and keratinocytes for different time periods. CM-AuX scaffold extracts were also nontoxic for 3T3 fibroblasts and keratinocytes. The L929 cell attachment and proliferation on CM-AuX were comparable with Matriderm, indicating good in vitro biocompatibility. As a whole, collagen matrices incorporated with AuNPs are potential biomaterial candidates for skin tissue engineering.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/58535</dc:identifier>
  <dc:identifier>oai:zenodo.org:58535</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>TURKISH JOURNAL OF BIOLOGY 40(2) 380-398</dc:source>
  <dc:title>Collagen/PEO/gold nanofibrous matrices for skin tissue engineering</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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