1 Ocak 2016 Dergi makalesi Açık Erişim

Akturk, Omer; Keskin, Dilek

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{
  "@context": "https://schema.org/", 
  "@id": 58535, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Middle E Tech Univ, Dept Engn Sci, TR-06531 Ankara, Turkey", 
      "name": "Akturk, Omer"
    }, 
    {
      "@type": "Person", 
      "name": "Keskin, Dilek"
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "As a novel approach in skin tissue engineering, gold nanoparticles (AuNPs) were synthesized and incorporated at different concentrations into collagen/PEO nanofibrous matrices in this study. The group containing 14.27 ppm AuNPs (CM-Au) had the best nanofibrous morphology. CM-Au was cross-linked with glutaraldehyde vapor (CM-AuX). All groups were disrupted in collagenase in 2 h, but cross-linked groups and Matriderm (R) resisted hydrolytic degradation for 7 and 14 days, respectively. Due to its small pores and dense structure, lower water swelling results (7.26 +/- 2.62 g/g) were obtained for CM-AuX than Matriderm (17.51 +/- 1.97 g/g). CM-Au and Matriderm had statistically similar tensile strength and elastic modulus, but elongation at break of CM-Au (over 100%) was significantly better than that of Matriderm. After cross-linking, tensile strength and elastic modulus of collagen matrix was further improved. AuNPs (37 and 42 nm) seemed to be nontoxic on 3T3 fibroblasts and keratinocytes for different time periods. CM-AuX scaffold extracts were also nontoxic for 3T3 fibroblasts and keratinocytes. The L929 cell attachment and proliferation on CM-AuX were comparable with Matriderm, indicating good in vitro biocompatibility. As a whole, collagen matrices incorporated with AuNPs are potential biomaterial candidates for skin tissue engineering.", 
  "headline": "Collagen/PEO/gold nanofibrous matrices for skin tissue engineering", 
  "identifier": 58535, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Collagen/PEO/gold nanofibrous matrices for skin tissue engineering", 
  "url": "https://aperta.ulakbim.gov.tr/record/58535"
}