1 Ocak 2016 Dergi makalesi Açık Erişim

Akturk, Omer; Keskin, Dilek

Citation Style Language JSON

{
  "DOI": "10.3906/biy-1502-49", 
  "abstract": "As a novel approach in skin tissue engineering, gold nanoparticles (AuNPs) were synthesized and incorporated at different concentrations into collagen/PEO nanofibrous matrices in this study. The group containing 14.27 ppm AuNPs (CM-Au) had the best nanofibrous morphology. CM-Au was cross-linked with glutaraldehyde vapor (CM-AuX). All groups were disrupted in collagenase in 2 h, but cross-linked groups and Matriderm (R) resisted hydrolytic degradation for 7 and 14 days, respectively. Due to its small pores and dense structure, lower water swelling results (7.26 +/- 2.62 g/g) were obtained for CM-AuX than Matriderm (17.51 +/- 1.97 g/g). CM-Au and Matriderm had statistically similar tensile strength and elastic modulus, but elongation at break of CM-Au (over 100%) was significantly better than that of Matriderm. After cross-linking, tensile strength and elastic modulus of collagen matrix was further improved. AuNPs (37 and 42 nm) seemed to be nontoxic on 3T3 fibroblasts and keratinocytes for different time periods. CM-AuX scaffold extracts were also nontoxic for 3T3 fibroblasts and keratinocytes. The L929 cell attachment and proliferation on CM-AuX were comparable with Matriderm, indicating good in vitro biocompatibility. As a whole, collagen matrices incorporated with AuNPs are potential biomaterial candidates for skin tissue engineering.", 
  "author": [
    {
      "family": "Akturk", 
      "given": " Omer"
    }, 
    {
      "family": "Keskin", 
      "given": " Dilek"
    }
  ], 
  "container_title": "TURKISH JOURNAL OF BIOLOGY", 
  "id": "58535", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "380-398", 
  "title": "Collagen/PEO/gold nanofibrous matrices for skin tissue engineering", 
  "type": "article-journal", 
  "volume": "40"
}