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Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

Topkaya, Derya; Lafont, Dominique; Poyer, Florent; Garcia, Guillaume; Albrieux, Florian; Maillard, Philippe; Bretonniere, Yann; Dumoulin, Fabienne


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  "@id": 56195, 
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    {
      "@type": "Person", 
      "name": "Topkaya, Derya"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Lyon 1, Inst Chim & Biochim Mol & Supramol, CO2 Glyco, UMR 5246,CNRS, 43 Blvd 11 Novembre 1918, F-6922 Villeurbanne, France", 
      "name": "Lafont, Dominique"
    }, 
    {
      "@type": "Person", 
      "name": "Poyer, Florent"
    }, 
    {
      "@type": "Person", 
      "name": "Garcia, Guillaume"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Lyon, CNRS Claude Bernard Lyon 1, Ctr Commun Spectrometrie Masse UMR 5246, Batiment Curien,43,Bd 11 Novembre, F-69622 Villeurbanne, France", 
      "name": "Albrieux, Florian"
    }, 
    {
      "@type": "Person", 
      "name": "Maillard, Philippe"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Lyon, Lab Chim ENS Lyon, UMR 5182, ENS Lyon,CNRS, 46 Alle Italie, F-69364 Lyon, France", 
      "name": "Bretonniere, Yann"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, POB 141, TR-41400 Gebze, Turkey", 
      "name": "Dumoulin, Fabienne"
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.", 
  "headline": "Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity", 
  "identifier": 56195, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity", 
  "url": "https://aperta.ulakbim.gov.tr/record/56195"
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