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Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

   Topkaya, Derya; Lafont, Dominique; Poyer, Florent; Garcia, Guillaume; Albrieux, Florian; Maillard, Philippe; Bretonniere, Yann; Dumoulin, Fabienne

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.

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