Dergi makalesi Açık Erişim
Yuksel, Melike; Biberoglu, Kevser; Onder, Seda; Akbulut, K. Gonca; Tacal, Ozden
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">BIOCHIMIE</subfield> <subfield code="v">146</subfield> <subfield code="c">105-112</subfield> </datafield> <controlfield tag="001">37007</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Recently, we have demonstrated that toluidine blue O (TBO), a phenothiazine dye, shows inhibitory effects on both cholinesterases and amyloid pathology in Alzheimer's disease (AD) cellular model. In the present study, we aimed to determine the effects of TBO (in a purity of 85%) on amyloid and tau pathologies in a triple transgenic mouse model of AD (3xTg-AD). Beginning at 7.5 (mild pathology) or 13 (severe pathology) months of age, 3xTg-AD mice were treated intraperitoneally with 4mg/kg TBO or vehicle daily for 30 days. TBO treatment significantly reduced the levels of insoluble A beta 40 and A beta 42 in the hippocampi of mild and severe pathology groups compared to vehicle-treated counterparts. When the levels of full-length amyloid precursor protein (APP) and beta-site APP-cleaving enzyme 1 (BACE1) were assessed in 3xTg-AD mice at late pathological stage, no significant changes were observed after TBO treatment. Similarly, TBO did not recover hyperphosphorylation of tau at residues Thr181 and Ser202/Thr205 significantly in soluble and insoluble hippocampal fractions of 3xTg-AD mice. Taken together, the current study is the first in vivo report, to our knowledge, demonstrating that TBO mitigates amyloid pathology in 3xTg-AD mice with no apparent change on tau phosphorylation. Overall, the preliminary data presented here support the possible use of TBO as a disease-modifying drug for AD treatment. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey</subfield> <subfield code="a">Biberoglu, Kevser</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey</subfield> <subfield code="a">Onder, Seda</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Gazi Univ, Sch Med, Dept Physiol, Ankara, Turkey</subfield> <subfield code="a">Akbulut, K. Gonca</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey</subfield> <subfield code="a">Tacal, Ozden</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey</subfield> <subfield code="a">Yuksel, Melike</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2018-01-01</subfield> </datafield> <controlfield tag="005">20210315194329.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:37007</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:196ebdab6f1ea875bd0b3cde991a7bf6</subfield> <subfield code="s">208</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/37007/files/bib-be050169-db21-4500-a683-c3e200399a59.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.biochi.2017.12.004</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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