1 Ocak 2018 Dergi makalesi Açık Erişim

Yuksel, Melike; Biberoglu, Kevser; Onder, Seda; Akbulut, K. Gonca; Tacal, Ozden

Citation Style Language JSON

{
  "DOI": "10.1016/j.biochi.2017.12.004", 
  "abstract": "Recently, we have demonstrated that toluidine blue O (TBO), a phenothiazine dye, shows inhibitory effects on both cholinesterases and amyloid pathology in Alzheimer's disease (AD) cellular model. In the present study, we aimed to determine the effects of TBO (in a purity of 85%) on amyloid and tau pathologies in a triple transgenic mouse model of AD (3xTg-AD). Beginning at 7.5 (mild pathology) or 13 (severe pathology) months of age, 3xTg-AD mice were treated intraperitoneally with 4mg/kg TBO or vehicle daily for 30 days. TBO treatment significantly reduced the levels of insoluble A beta 40 and A beta 42 in the hippocampi of mild and severe pathology groups compared to vehicle-treated counterparts. When the levels of full-length amyloid precursor protein (APP) and beta-site APP-cleaving enzyme 1 (BACE1) were assessed in 3xTg-AD mice at late pathological stage, no significant changes were observed after TBO treatment. Similarly, TBO did not recover hyperphosphorylation of tau at residues Thr181 and Ser202/Thr205 significantly in soluble and insoluble hippocampal fractions of 3xTg-AD mice. Taken together, the current study is the first in vivo report, to our knowledge, demonstrating that TBO mitigates amyloid pathology in 3xTg-AD mice with no apparent change on tau phosphorylation. Overall, the preliminary data presented here support the possible use of TBO as a disease-modifying drug for AD treatment. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.", 
  "author": [
    {
      "family": "Yuksel", 
      "given": " Melike"
    }, 
    {
      "family": "Biberoglu", 
      "given": " Kevser"
    }, 
    {
      "family": "Onder", 
      "given": " Seda"
    }, 
    {
      "family": "Akbulut", 
      "given": " K. Gonca"
    }, 
    {
      "family": "Tacal", 
      "given": " Ozden"
    }
  ], 
  "container_title": "BIOCHIMIE", 
  "id": "37007", 
  "issued": {
    "date-parts": [
      [
        2018, 
        1, 
        1
      ]
    ]
  }, 
  "page": "105-112", 
  "title": "Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease", 
  "type": "article-journal", 
  "volume": "146"
}