1 Ocak 2018 Dergi makalesi Açık Erişim

Yuksel, Melike; Biberoglu, Kevser; Onder, Seda; Akbulut, K. Gonca; Tacal, Ozden

JSON

{
  "conceptrecid": "37006", 
  "created": "2021-03-15T19:43:29.138369+00:00", 
  "doi": "10.1016/j.biochi.2017.12.004", 
  "files": [
    {
      "bucket": "0bc2dfdb-4121-4b3d-a8e6-8a6d3d77f50e", 
      "checksum": "md5:196ebdab6f1ea875bd0b3cde991a7bf6", 
      "key": "bib-be050169-db21-4500-a683-c3e200399a59.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/0bc2dfdb-4121-4b3d-a8e6-8a6d3d77f50e/bib-be050169-db21-4500-a683-c3e200399a59.txt"
      }, 
      "size": 208, 
      "type": "txt"
    }
  ], 
  "id": 37007, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1016/j.biochi.2017.12.004.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/0bc2dfdb-4121-4b3d-a8e6-8a6d3d77f50e", 
    "doi": "https://doi.org/10.1016/j.biochi.2017.12.004", 
    "html": "https://aperta.ulakbim.gov.tr/record/37007", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/37007", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/37007"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey", 
        "name": "Yuksel, Melike"
      }, 
      {
        "affiliation": "Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey", 
        "name": "Biberoglu, Kevser"
      }, 
      {
        "affiliation": "Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey", 
        "name": "Onder, Seda"
      }, 
      {
        "affiliation": "Gazi Univ, Sch Med, Dept Physiol, Ankara, Turkey", 
        "name": "Akbulut, K. Gonca"
      }, 
      {
        "affiliation": "Hacettepe Univ, Sch Pharm, Dept Biochem, TR-06100 Ankara, Turkey", 
        "name": "Tacal, Ozden"
      }
    ], 
    "description": "Recently, we have demonstrated that toluidine blue O (TBO), a phenothiazine dye, shows inhibitory effects on both cholinesterases and amyloid pathology in Alzheimer's disease (AD) cellular model. In the present study, we aimed to determine the effects of TBO (in a purity of 85%) on amyloid and tau pathologies in a triple transgenic mouse model of AD (3xTg-AD). Beginning at 7.5 (mild pathology) or 13 (severe pathology) months of age, 3xTg-AD mice were treated intraperitoneally with 4mg/kg TBO or vehicle daily for 30 days. TBO treatment significantly reduced the levels of insoluble A beta 40 and A beta 42 in the hippocampi of mild and severe pathology groups compared to vehicle-treated counterparts. When the levels of full-length amyloid precursor protein (APP) and beta-site APP-cleaving enzyme 1 (BACE1) were assessed in 3xTg-AD mice at late pathological stage, no significant changes were observed after TBO treatment. Similarly, TBO did not recover hyperphosphorylation of tau at residues Thr181 and Ser202/Thr205 significantly in soluble and insoluble hippocampal fractions of 3xTg-AD mice. Taken together, the current study is the first in vivo report, to our knowledge, demonstrating that TBO mitigates amyloid pathology in 3xTg-AD mice with no apparent change on tau phosphorylation. Overall, the preliminary data presented here support the possible use of TBO as a disease-modifying drug for AD treatment. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.", 
    "doi": "10.1016/j.biochi.2017.12.004", 
    "has_grant": false, 
    "journal": {
      "pages": "105-112", 
      "title": "BIOCHIMIE", 
      "volume": "146"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2018-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "37007"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "37006"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 5.0, 
    "unique_downloads": 5.0, 
    "unique_views": 27.0, 
    "version_downloads": 5.0, 
    "version_unique_downloads": 5.0, 
    "version_unique_views": 27.0, 
    "version_views": 29.0, 
    "version_volume": 1040.0, 
    "views": 29.0, 
    "volume": 1040.0
  }, 
  "updated": "2021-03-15T19:43:29.192101+00:00"
}