1 Ocak 2018 Dergi makalesi Açık Erişim

Akbay, Nuriye; Tok, Tugba Taskin; Seferoglu, Zeynel; Gokoglu, Elmas

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{
  "@context": "https://schema.org/", 
  "@id": 33043, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Istanbul Medeniyet Univ, Dept Chem, TR-34700 Istanbul, Turkey", 
      "name": "Akbay, Nuriye"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gaziantep Univ, Dept Chem, TR-27310 Gaziantep, Turkey", 
      "name": "Tok, Tugba Taskin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Dept Chem, TR-06500 Ankara, Turkey", 
      "name": "Seferoglu, Zeynel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Gokoglu, Elmas"
    }
  ], 
  "datePublished": "2018-01-01", 
  "description": "The interaction mechanisms of two ethidium derivatives, 3,8-dibenzoylamino-5-ethyl-6-phenylphenantridinium chloride (E2) and 3,8-diphenylacetylamino-5-ethyl-6-phenylphenantridinium chloride (E3) with serum albumins (BSA and HSA) have been investigated by a combined experimental and computational approach. Fluorescence quenching and UV-vis results revealed that the interaction of derivatives with albumins resulted in formation of ground-state complexes and the obtained Stern-Volmer quenching constants designate the presence of a static component in the quenching mechanisms. Thermodynamic parameters (H and S values) point out the ionic interactions play the major role in E2-BSA, E2-HSA and E3-HSA complexes. The van der Waals interactions are dominant forces in E3-BSA complex. Moreover, the obtained results in this study were supported with computational analyzes which have same tendency.", 
  "headline": "Investigation of binding properties of two ethidium derivatives with serum albumins: spectral and computational approach", 
  "identifier": 33043, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Investigation of binding properties of two ethidium derivatives with serum albumins: spectral and computational approach", 
  "url": "https://aperta.ulakbim.gov.tr/record/33043"
}