1 Ocak 2018 Dergi makalesi Açık Erişim

Akbay, Nuriye; Tok, Tugba Taskin; Seferoglu, Zeynel; Gokoglu, Elmas

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/33043</identifier>
  <creators>
    <creator>
      <creatorName>Akbay, Nuriye</creatorName>
      <givenName>Nuriye</givenName>
      <familyName>Akbay</familyName>
      <affiliation>Istanbul Medeniyet Univ, Dept Chem, TR-34700 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tok, Tugba Taskin</creatorName>
      <givenName>Tugba Taskin</givenName>
      <familyName>Tok</familyName>
      <affiliation>Gaziantep Univ, Dept Chem, TR-27310 Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Seferoglu, Zeynel</creatorName>
      <givenName>Zeynel</givenName>
      <familyName>Seferoglu</familyName>
      <affiliation>Gazi Univ, Dept Chem, TR-06500 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gokoglu, Elmas</creatorName>
      <givenName>Elmas</givenName>
      <familyName>Gokoglu</familyName>
      <affiliation>Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Investigation Of Binding Properties Of Two Ethidium Derivatives With Serum Albumins: Spectral And Computational Approach</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/33043</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/07391102.2017.1380536</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The interaction mechanisms of two ethidium derivatives, 3,8-dibenzoylamino-5-ethyl-6-phenylphenantridinium chloride (E2) and 3,8-diphenylacetylamino-5-ethyl-6-phenylphenantridinium chloride (E3) with serum albumins (BSA and HSA) have been investigated by a combined experimental and computational approach. Fluorescence quenching and UV-vis results revealed that the interaction of derivatives with albumins resulted in formation of ground-state complexes and the obtained Stern-Volmer quenching constants designate the presence of a static component in the quenching mechanisms. Thermodynamic parameters (H and S values) point out the ionic interactions play the major role in E2-BSA, E2-HSA and E3-HSA complexes. The van der Waals interactions are dominant forces in E3-BSA complex. Moreover, the obtained results in this study were supported with computational analyzes which have same tendency.</description>
  </descriptions>
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