1 Ocak 2018 Dergi makalesi Açık Erişim

Akbay, Nuriye; Tok, Tugba Taskin; Seferoglu, Zeynel; Gokoglu, Elmas

Citation Style Language JSON

{
  "DOI": "10.1080/07391102.2017.1380536", 
  "abstract": "The interaction mechanisms of two ethidium derivatives, 3,8-dibenzoylamino-5-ethyl-6-phenylphenantridinium chloride (E2) and 3,8-diphenylacetylamino-5-ethyl-6-phenylphenantridinium chloride (E3) with serum albumins (BSA and HSA) have been investigated by a combined experimental and computational approach. Fluorescence quenching and UV-vis results revealed that the interaction of derivatives with albumins resulted in formation of ground-state complexes and the obtained Stern-Volmer quenching constants designate the presence of a static component in the quenching mechanisms. Thermodynamic parameters (H and S values) point out the ionic interactions play the major role in E2-BSA, E2-HSA and E3-HSA complexes. The van der Waals interactions are dominant forces in E3-BSA complex. Moreover, the obtained results in this study were supported with computational analyzes which have same tendency.", 
  "author": [
    {
      "family": "Akbay", 
      "given": " Nuriye"
    }, 
    {
      "family": "Tok", 
      "given": " Tugba Taskin"
    }, 
    {
      "family": "Seferoglu", 
      "given": " Zeynel"
    }, 
    {
      "family": "Gokoglu", 
      "given": " Elmas"
    }
  ], 
  "container_title": "JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS", 
  "id": "33043", 
  "issue": "12", 
  "issued": {
    "date-parts": [
      [
        2018, 
        1, 
        1
      ]
    ]
  }, 
  "page": "3114-3121", 
  "title": "Investigation of binding properties of two ethidium derivatives with serum albumins: spectral and computational approach", 
  "type": "article-journal", 
  "volume": "36"
}