1 Ocak 2018 Dergi makalesi Açık Erişim

Gorgulu, G.; Cicek, M. B.; Dede, B.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/32521</identifier>
  <creators>
    <creator>
      <creatorName>Gorgulu, G.</creatorName>
      <givenName>G.</givenName>
      <familyName>Gorgulu</familyName>
      <affiliation>Mehmet Akif Ersoy Univ, Fac Educ, Burdur, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cicek, M. B.</creatorName>
      <givenName>M. B.</givenName>
      <familyName>Cicek</familyName>
      <affiliation>Suleyman Demirel Univ, Fac Sci &amp; Arts, Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dede, B.</creatorName>
      <givenName>B.</givenName>
      <familyName>Dede</familyName>
      <affiliation>Suleyman Demirel Univ, Fac Sci &amp; Arts, Isparta, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Novel Aminoketooxime Ligand And Its Cu(Ii) And Mn(Ii) Complexes: Synthesis, Characterization And Molecular Docking Studies</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/32521</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.12693/APhysPolA.133.250</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">A novel ligand, N, N ''-(4-methyl-1,2-phenylene)bis(2-(biphenyl-4-yl)-N'-hydroxy-2-oxoacetimidamide) (H2L) with its Cu(II) and Mn(II) complexes were synthesized in this study. All compounds synthesized were also characterized by H-1- and C-13-NMR, the Fourier transform infrared, elemental analysis, inductively coupled plasma optical emission spectrometry, molar conductivity, magnetic susceptibility measurements and thermogravimetric analysis. Vascular endothelial growth factor-2 (VEGFR-2) and cyclooxygenase-2 (COX-2) inhibition is often used as a parameter for being a potent anticancer agent in docking studies. For this purpose, synthesized and characterized ligand was investigated by molecular docking study to test its inhibitory effect against angiogenic factors VEGFR-2 and COX-2.</description>
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