1 Ocak 2018 Dergi makalesi Açık Erişim

Kilic, Sevgi

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{
  "@context": "https://schema.org/", 
  "@id": 28691, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Izmir Inst Technol, Dept Chem Engn, TR-35430 Izmir, Turkey", 
      "name": "Kilic, Sevgi"
    }
  ], 
  "datePublished": "2018-01-01", 
  "description": "Mixtures of 1,2 Distearoyl-sn-glycero-3-phosphocholine (DSPC) and polyoxyethylene-40-stearate (PEG(40)St) were prepared at different molar ratios and their miscibility were investigated using Langmuir isotherms. Pure DSPC monolayer exhibited a liquid-condensed (LC) phase whereas PEG(40)St monolayer exhibited liquid-expanded (LE) phase at the air-water interface at 22 +/- 2 degrees C. At the collapse pressure of 33 mN/m, the PEG(40)St mean molecular area was calculated to be 28 angstrom(2)/molecule for 9: 1 composition and 50 angstrom(2)/molecule for 5: 5 composition, showing an increasing trend with the emulsifier content. A quantification method was developed to estimate the squeeze out amount of PEG(40)St from Langmuir isotherms of the DSPC/PEG(40)St mixtures at different molar ratios. Almost 93%, 82%, and 53% of PEG(40)St displaced for the 9:1, 7:3, and 5:5 mixtures, respectively, at the end of the first collapse plateau and showed a decreasing trend with the PEG(40)St content. Remaining PEG(40)St squeezed out at the end of the second collapse plateau, where 20% of PEG(40)St still contained within the 5: 5 composition. It was concluded that increasing PEG(40)St content would be advantageous to design more stable lipid based microbubbles.", 
  "headline": "Quantification of PEG(40)St squeeze out from DSPC/PEG(40)St monolayers at higher molar ratios", 
  "identifier": 28691, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Quantification of PEG(40)St squeeze out from DSPC/PEG(40)St monolayers at higher molar ratios", 
  "url": "https://aperta.ulakbim.gov.tr/record/28691"
}