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Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzelii

Lannang, Alain Meli; Louh, Gabin Nselapi; Biloa, Bernadette Messi; Komguem, Justin; Mbazoa, Celine Djama; Sondengam, Beiban Luc; Naesens, Lieve; Pannecouque, Christophe; De Clercq, Erik; El Ashry, El Sayed H.


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{
  "DOI": "10.1055/s-0029-1240627", 
  "abstract": "The new compounds guttiferone O (1) and 3-methoxycheffouxanthone (2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (3), smeathxanthone A (4), 1,5-dihydroxyxanthone (5), 1,6-dihydroxy-5-methoxyxanthone (6), cheffouxanthone (7), 1,3,5-trihydroxyxanthone (8), smeathxanthone B (9), isoxanthochymol (10) and guttiferone E (11). Their structures were elucidated by means of 1D and 2D-NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.", 
  "author": [
    {
      "family": "Lannang", 
      "given": " Alain Meli"
    }, 
    {
      "family": "Louh", 
      "given": " Gabin Nselapi"
    }, 
    {
      "family": "Biloa", 
      "given": " Bernadette Messi"
    }, 
    {
      "family": "Komguem", 
      "given": " Justin"
    }, 
    {
      "family": "Mbazoa", 
      "given": " Celine Djama"
    }, 
    {
      "family": "Sondengam", 
      "given": " Beiban Luc"
    }, 
    {
      "family": "Naesens", 
      "given": " Lieve"
    }, 
    {
      "family": "Pannecouque", 
      "given": " Christophe"
    }, 
    {
      "family": "De Clercq", 
      "given": " Erik"
    }, 
    {
      "family": "El Ashry", 
      "given": " El Sayed H."
    }
  ], 
  "container_title": "PLANTA MEDICA", 
  "id": "28339", 
  "issue": "7", 
  "issued": {
    "date-parts": [
      [
        2010, 
        1, 
        1
      ]
    ]
  }, 
  "page": "708-712", 
  "title": "Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzelii", 
  "type": "article-journal", 
  "volume": "76"
}
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