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Self-assembly of organocatalysts for the enantioselective Michael addition of aldehydes to nitroalkenes

Demir, Ayhan S.; Eymur, Serkan


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        "affiliation": "Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey", 
        "name": "Demir, Ayhan S."
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        "affiliation": "Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey", 
        "name": "Eymur, Serkan"
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    "description": "A proline-thiourea self-assembled organocatalyst is described as a good catalyst for the enantioselective nitro-Michael addition of aldehydes to nitroalkenes The reaction is efficient with 5% of the thiourea, to give moderate to good enantioselectivity (up to 76% ee) High syn-selectivity was obtained with both branched and unbranched aliphatic aldehydes This is the first example of self-assembly of organocatalysts with an achiral additive in a Michael addition wherein aldehydes are utilized as donors. (c) 2009 Elsevier Ltd All rights reserved", 
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      "issue": "1", 
      "pages": "112-115", 
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