Dergi makalesi Açık Erişim
Barbai, V. H.; Ujhelyi, E.; Szlavik, J.; Vietorisz, I.; Varga, L.; Fey, E.; Fust, G.; Banhegyi, D.
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Ujhelyi, E.</subfield> <subfield code="u">Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Immunol, H-1097 Budapest, Hungary</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Szlavik, J.</subfield> <subfield code="u">Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Trop Dis, H-1097 Budapest, Hungary</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Vietorisz, I.</subfield> <subfield code="u">Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Clin Chem, H-1097 Budapest, Hungary</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Varga, L.</subfield> <subfield code="u">Semmelweis Univ, Dept Internal Med 3, Budapest, Hungary</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Fey, E.</subfield> <subfield code="u">Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Clin Chem, H-1097 Budapest, Hungary</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Fust, G.</subfield> <subfield code="u">Semmelweis Univ, Dept Internal Med 3, Budapest, Hungary</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Banhegyi, D.</subfield> <subfield code="u">Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Trop Dis, H-1097 Budapest, Hungary</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">CLINICAL AND EXPERIMENTAL IMMUNOLOGY</subfield> <subfield code="v">161</subfield> <subfield code="n">1</subfield> <subfield code="c">134-141</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Creative Commons Attribution</subfield> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1111/j.1365-2249.2010.04145.x</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Changes in the levels of some acute-phase proteins in human immunodeficiency virus-1 infected patients, following interleukin-2 treatment</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Barbai, V. H.</subfield> <subfield code="u">Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Immunol, H-1097 Budapest, Hungary</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:27023</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2010-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/27023/files/bib-506d87b3-eda7-4ea0-bc82-5b9ac25266c2.txt</subfield> <subfield code="z">md5:c8adf37e1f74e24e40aa9353e8c3c1d2</subfield> <subfield code="s">298</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <controlfield tag="005">20210315121607.0</controlfield> <controlfield tag="001">27023</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">P&gt;Intermittent interleukin (IL)-2 administration to human immunodeficiency virus (HIV)-1 infected patients is well documented and generally used, but there is limited information about the changes of acute-phase protein (APP) levels in response to this treatment. Fifteen patients undergoing highly active anti-retroviral therapy (HAART) treatment, with undetectable viral load, but low CD4+ cell count (&lt; 300/mu l), have been treated with 3 center dot 6 M IU Proleukine (R) administered twice daily by subcutaneous injection over 5 days. C-reactive protein (CRP), d-dimer, C3, C9, C1-inh and alpha-2HS glycoprotein levels were measured immediately before IL-2 administration, as well as on day 5 and 2-3 weeks thereafter. After IL-2 administration, both mean d-dimer and CRP levels increased significantly (P &lt; 0 center dot 001), but returned (P &lt; 0 center dot 001) to baseline within the subsequent 2-3 weeks. Alpha-2HS glycoprotein decreased immediately after IL-2 administration. No significant differences were detected in the levels of C3, C9 and C1-inh. A significant, positive correlation (r = 0 center dot 5178, P = 0 center dot 0008) was ascertained between the changes of CRP level, measured immediately before as well as 5 days after IL-2 administration, and changes in CD4 T cell counts measured 2-3 weeks before and after treatment, respectively. IL-2 administration induces rapid elevation of two major APPs (CRP, d-dimer). The positive correlation observed between the changes of CRP levels and CD4+ cell counts after IL-2 administration may indicate that the abrupt, but transitory overproduction of CRP might contribute to the CD4+ cell count-increasing effect of the drug and/ or may be associated with serious side effects.</subfield> </datafield> </record>
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