1 Ocak 2010 Dergi makalesi Açık Erişim

Barbai, V. H.; Ujhelyi, E.; Szlavik, J.; Vietorisz, I.; Varga, L.; Fey, E.; Fust, G.; Banhegyi, D.

Citation Style Language JSON

{
  "DOI": "10.1111/j.1365-2249.2010.04145.x", 
  "abstract": "P>Intermittent interleukin (IL)-2 administration to human immunodeficiency virus (HIV)-1 infected patients is well documented and generally used, but there is limited information about the changes of acute-phase protein (APP) levels in response to this treatment. Fifteen patients undergoing highly active anti-retroviral therapy (HAART) treatment, with undetectable viral load, but low CD4+ cell count (< 300/mu l), have been treated with 3 center dot 6 M IU Proleukine (R) administered twice daily by subcutaneous injection over 5 days. C-reactive protein (CRP), d-dimer, C3, C9, C1-inh and alpha-2HS glycoprotein levels were measured immediately before IL-2 administration, as well as on day 5 and 2-3 weeks thereafter. After IL-2 administration, both mean d-dimer and CRP levels increased significantly (P < 0 center dot 001), but returned (P < 0 center dot 001) to baseline within the subsequent 2-3 weeks. Alpha-2HS glycoprotein decreased immediately after IL-2 administration. No significant differences were detected in the levels of C3, C9 and C1-inh. A significant, positive correlation (r = 0 center dot 5178, P = 0 center dot 0008) was ascertained between the changes of CRP level, measured immediately before as well as 5 days after IL-2 administration, and changes in CD4 T cell counts measured 2-3 weeks before and after treatment, respectively. IL-2 administration induces rapid elevation of two major APPs (CRP, d-dimer). The positive correlation observed between the changes of CRP levels and CD4+ cell counts after IL-2 administration may indicate that the abrupt, but transitory overproduction of CRP might contribute to the CD4+ cell count-increasing effect of the drug and/ or may be associated with serious side effects.", 
  "author": [
    {
      "family": "Barbai", 
      "given": " V. H."
    }, 
    {
      "family": "Ujhelyi", 
      "given": " E."
    }, 
    {
      "family": "Szlavik", 
      "given": " J."
    }, 
    {
      "family": "Vietorisz", 
      "given": " I."
    }, 
    {
      "family": "Varga", 
      "given": " L."
    }, 
    {
      "family": "Fey", 
      "given": " E."
    }, 
    {
      "family": "Fust", 
      "given": " G."
    }, 
    {
      "family": "Banhegyi", 
      "given": " D."
    }
  ], 
  "container_title": "CLINICAL AND EXPERIMENTAL IMMUNOLOGY", 
  "id": "27023", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2010, 
        1, 
        1
      ]
    ]
  }, 
  "page": "134-141", 
  "title": "Changes in the levels of some acute-phase proteins in human immunodeficiency virus-1 infected patients, following interleukin-2 treatment", 
  "type": "article-journal", 
  "volume": "161"
}