1 Ocak 2010 Dergi makalesi Açık Erişim

Barbai, V. H.; Ujhelyi, E.; Szlavik, J.; Vietorisz, I.; Varga, L.; Fey, E.; Fust, G.; Banhegyi, D.

JSON

{
  "conceptrecid": "27022", 
  "created": "2021-03-15T12:16:07.686950+00:00", 
  "doi": "10.1111/j.1365-2249.2010.04145.x", 
  "files": [
    {
      "bucket": "878afaa5-69e9-4e77-9164-e2caa2a120a4", 
      "checksum": "md5:c8adf37e1f74e24e40aa9353e8c3c1d2", 
      "key": "bib-506d87b3-eda7-4ea0-bc82-5b9ac25266c2.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/878afaa5-69e9-4e77-9164-e2caa2a120a4/bib-506d87b3-eda7-4ea0-bc82-5b9ac25266c2.txt"
      }, 
      "size": 298, 
      "type": "txt"
    }
  ], 
  "id": 27023, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1111/j.1365-2249.2010.04145.x.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/878afaa5-69e9-4e77-9164-e2caa2a120a4", 
    "doi": "https://doi.org/10.1111/j.1365-2249.2010.04145.x", 
    "html": "https://aperta.ulakbim.gov.tr/record/27023", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/27023", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/27023"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Immunol, H-1097 Budapest, Hungary", 
        "name": "Barbai, V. H."
      }, 
      {
        "affiliation": "Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Immunol, H-1097 Budapest, Hungary", 
        "name": "Ujhelyi, E."
      }, 
      {
        "affiliation": "Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Trop Dis, H-1097 Budapest, Hungary", 
        "name": "Szlavik, J."
      }, 
      {
        "affiliation": "Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Clin Chem, H-1097 Budapest, Hungary", 
        "name": "Vietorisz, I."
      }, 
      {
        "affiliation": "Semmelweis Univ, Dept Internal Med 3, Budapest, Hungary", 
        "name": "Varga, L."
      }, 
      {
        "affiliation": "Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Clin Chem, H-1097 Budapest, Hungary", 
        "name": "Fey, E."
      }, 
      {
        "affiliation": "Semmelweis Univ, Dept Internal Med 3, Budapest, Hungary", 
        "name": "Fust, G."
      }, 
      {
        "affiliation": "Fovarosi Onkormanyzat Egyesitett Szent Istvan & S, Dept Trop Dis, H-1097 Budapest, Hungary", 
        "name": "Banhegyi, D."
      }
    ], 
    "description": "P>Intermittent interleukin (IL)-2 administration to human immunodeficiency virus (HIV)-1 infected patients is well documented and generally used, but there is limited information about the changes of acute-phase protein (APP) levels in response to this treatment. Fifteen patients undergoing highly active anti-retroviral therapy (HAART) treatment, with undetectable viral load, but low CD4+ cell count (< 300/mu l), have been treated with 3 center dot 6 M IU Proleukine (R) administered twice daily by subcutaneous injection over 5 days. C-reactive protein (CRP), d-dimer, C3, C9, C1-inh and alpha-2HS glycoprotein levels were measured immediately before IL-2 administration, as well as on day 5 and 2-3 weeks thereafter. After IL-2 administration, both mean d-dimer and CRP levels increased significantly (P < 0 center dot 001), but returned (P < 0 center dot 001) to baseline within the subsequent 2-3 weeks. Alpha-2HS glycoprotein decreased immediately after IL-2 administration. No significant differences were detected in the levels of C3, C9 and C1-inh. A significant, positive correlation (r = 0 center dot 5178, P = 0 center dot 0008) was ascertained between the changes of CRP level, measured immediately before as well as 5 days after IL-2 administration, and changes in CD4 T cell counts measured 2-3 weeks before and after treatment, respectively. IL-2 administration induces rapid elevation of two major APPs (CRP, d-dimer). The positive correlation observed between the changes of CRP levels and CD4+ cell counts after IL-2 administration may indicate that the abrupt, but transitory overproduction of CRP might contribute to the CD4+ cell count-increasing effect of the drug and/ or may be associated with serious side effects.", 
    "doi": "10.1111/j.1365-2249.2010.04145.x", 
    "has_grant": false, 
    "journal": {
      "issue": "1", 
      "pages": "134-141", 
      "title": "CLINICAL AND EXPERIMENTAL IMMUNOLOGY", 
      "volume": "161"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2010-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "27023"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "27022"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Changes in the levels of some acute-phase proteins in human immunodeficiency virus-1 infected patients, following interleukin-2 treatment"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 11.0, 
    "unique_downloads": 11.0, 
    "unique_views": 32.0, 
    "version_downloads": 11.0, 
    "version_unique_downloads": 11.0, 
    "version_unique_views": 32.0, 
    "version_views": 37.0, 
    "version_volume": 3278.0, 
    "views": 37.0, 
    "volume": 3278.0
  }, 
  "updated": "2021-03-15T12:16:07.726399+00:00"
}