1 Ocak 2023 Dergi makalesi Açık Erişim

Ozyilmaz, Elif; Caglar, Ozge

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        "affiliation": "Selcuk Univ, Dept Biochem, TR-42075 Konya, Turkiye", 
        "name": "Ozyilmaz, Elif"
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      {
        "name": "Caglar, Ozge"
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    "description": "<p>The mechanochemical encapsulation of enzymes during the synthesis of metal-organic frameworks (MOF) have been thought to be a natural, economical, new, and environmentally friendly step in synthesizing supported enzymatic catalysts. In this study, for the first time, a mechanochemical technique was employed to immobilize Candida rugosa lipase (CRL), and two zinc-based MOF types (Zn-MOF-74 and ZIF-8) were preferred. The enzyme kinetics and immobilization parameters (pH, temperature, thermal stability and reusability) of the prepared encapsulated enzymes (Zn-MOF-74@CRL and ZIF-8@CRL) were investigated. The prepared encapsulated enzymes were characterized by FTIR, SEM and XRD. It was observed that the catalytic activity of Zn-MOF-74 @CRL was six times higher than that of ZIF-8@CRL. After five reuses, the activities of Zn-MOF-74@CRL and ZIF-8@CRL were found to be 81% and 73% retained, respectively. After being subjected to 60 degrees C for 120 min, ZIF-8@CRL and Zn-MOF-74@CRL maintained their activities at 65% and 73%, respectively. The enantioselective hydrolysis reaction of racemic naproxen methyl ester was chosen as the model reaction. The results showed Zn-MOF-74@CRL possessed better enantioselectivity (E = 245) than ZIF-8@CRL (E = 136). This study demonstrated that it is possible to create biocatalysts with excellent catalytic properties for the pharmaceutical industry using MOFs produced by the mechanochemical method.</p>", 
    "doi": "10.1016/j.procbio.2023.10.002", 
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      "pages": "10", 
      "title": "PROCESS BIOCHEMISTRY", 
      "volume": "134"
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    "publication_date": "2023-01-01", 
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    "title": "Rapid mechanochemical production of biocomposites by encapsulating enzymes to zinc based-two metal organic frameworks (ZIF-8 and Zn-MOF-74) for enantioselective hydrolysis reaction of racemic Naproxen methyl ester"
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