1 Ocak 2023 Dergi makalesi Açık Erişim

Isil, Turp; Ozlem, Kara; Defne, Burduroglu Hatice; Eray, Guler Metin; Abdurrahim, Kocyigit

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/267364</identifier>
  <creators>
    <creator>
      <creatorName>Isil, Turp</creatorName>
      <givenName>Turp</givenName>
      <familyName>Isil</familyName>
      <affiliation>Bezmialem Vakif Univ, Fac Dent, Dept Prosthodont, Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Ozlem, Kara</creatorName>
      <givenName>Kara</givenName>
      <familyName>Ozlem</familyName>
      <affiliation>Bezmialem Vakif Univ, Fac Dent, Dept Prosthodont, Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Defne, Burduroglu Hatice</creatorName>
      <givenName>Burduroglu Hatice</givenName>
      <familyName>Defne</familyName>
      <affiliation>President Clin, Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Eray, Guler Metin</creatorName>
      <givenName>Guler Metin</givenName>
      <familyName>Eray</familyName>
    </creator>
    <creator>
      <creatorName>Abdurrahim, Kocyigit</creatorName>
      <givenName>Kocyigit</givenName>
      <familyName>Abdurrahim</familyName>
      <affiliation>Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Toxicity Evaluation Of Indocyanine Green Mediated Photodynamic Therapy</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2023</publicationYear>
  <dates>
    <date dateType="Issued">2023-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/267364</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.pdpdt.2023.103754</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Background: The aim of the study is to determine the cytotoxic, genotoxic and inflammatory effects of indocyanine green (ICG) mediated photodynamic therapy (PDT) in direct contact with L-929 mouse fibroblast cells and over a dentin barrier.Methods: Eight groups were evaluated; control (C), group with a dentin barrier (D), ICG applied directly on the cells (ICG), ICG applied over a dentin barrier (D-ICG), only laser applied (L), laser applied over a dentin barrier (D-L), ICG and laser applied directly on the cells (ICG-L), ICG and laser applied over a dentin barrier (D-ICG-L). Cell viability was evaluated via ATP Assay, DNA damage was evaluated via Comet Assay, and inflammatory markers IL-1I3 and TNF-a were assessed via ELISA test.Results: Cell viability decreased in group ICG (p&amp;lt;0.001). Cell viability decrease was higher in Group ICG-L (p&amp;lt;0.001). Cell viability decrease was lower in group D-ICG-L (p&amp;gt;0.05). Group L caused an increase in cell number (p&amp;lt;0.001). DNA damage was observed in ICG, D-ICG, and ICG-L groups (p&amp;lt;0.05). None of the groups displayed an increase of inflammatory markers IL-1I3 and TNF-a (p&amp;gt;0.05).Conclusions: The presence of dentin between ICG and cells acted as a barrier and protected the cells. ICGmediated PDT did not cause any cytotoxic, genotoxic or inflammatory effect. The use of ICG-mediated PDT for cavity disinfection is acceptable, but at this concentration its use in periodontal pocket disinfection is not recommended due to its cytotoxic and genotoxic properties.&lt;/p&gt;</description>
  </descriptions>
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