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<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Methionine restriction and cancer treatment: a systems biology study of yeast to investigate the possible key players</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.48623/aperta.252436</subfield> <subfield code="2">doi</subfield> </datafield> <controlfield tag="001">252436</controlfield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p><strong>Background/Aim:</strong> Dietary restriction, mainly carbon and/or methionine restriction are among the upcoming supporting interventions along with chemotherapy in various cancers. Although dietary restriction has been proven to be beneficial, main cellular machineries affected by its administration lacks deeper information considerably, a notable pitfall on its use as a personalized nutritional approach.</p> <p><strong>Materials and methods:</strong> In this study, cellular effects of methionine restriction on a yeast model are explored <em>via</em> systems biology approaches. The methionine biosynthesis network, constructed by integrating interaction data with gene ontology terms, was analyzed topologically, and proved to be informative about the intertwined relationship of methionine biosynthesis and cancer. Experimentally, effects of methionine restriction on the yeast model were explored <em>in vivo,</em> with transcriptome analyses.</p> <p><strong>Results: </strong>The integrative analysis of the transcriptional data together with the reconstructed network gave insight into cellular machineries such as TOR, MAPK and sphingolipid-mediated signaling cascades as the mostly responsive cellular pathways in the methionine-restricted cases with Sch9p (functional orthologue of mammalian S6 kinase) being placed at the intersection of these signaling routes.</p></subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="0">(orcid)0000-0002-1326-0608</subfield> <subfield code="u">Koç University Hospital</subfield> <subfield code="a">Esra Börklü</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Methionine restriction</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">cancer</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">transcriptomics</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">systems biology</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">network analysis</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2023-05-23</subfield> </datafield> <controlfield tag="005">20230526080432.0</controlfield> <datafield tag="773" ind1=" " ind2=" "> <subfield code="n">doi</subfield> <subfield code="a">10.48623/aperta.252435</subfield> <subfield code="i">isVersionOf</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:aperta.ulakbim.gov.tr:252436</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:83711cce514b7e836397328b3bd56640</subfield> <subfield code="s">57061</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/252436/files/Supp Table 1.xlsx</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">https://creativecommons.org/licenses/by-nc/4.0/</subfield> <subfield code="a">Creative Commons Attribution-NonCommercial</subfield> </datafield> </record>
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