23 Mayıs 2023 Dergi makalesi Açık Erişim

Esra Börklü

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        "affiliation": "Ko\u00e7 University Hospital", 
        "name": "Esra B\u00f6rkl\u00fc", 
        "orcid": "0000-0002-1326-0608"
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    "description": "<p><strong>Background/Aim:</strong> Dietary restriction, mainly carbon and/or methionine restriction are among the upcoming supporting interventions along with chemotherapy in various cancers. Although dietary restriction has been proven to be beneficial, main cellular machineries affected by its administration lacks deeper information considerably, a notable pitfall on its use as a personalized nutritional approach.</p>\n\n<p><strong>Materials and methods:</strong> In this study, cellular effects of methionine restriction on a yeast model are explored <em>via</em> systems biology approaches. The methionine biosynthesis network, constructed by integrating interaction data with gene ontology terms, was analyzed topologically, and proved to be informative about the intertwined relationship of methionine biosynthesis and cancer. Experimentally, effects of methionine restriction on the yeast model were explored <em>in vivo,</em> with transcriptome analyses.</p>\n\n<p><strong>Results: </strong>The integrative analysis of the transcriptional data together with the reconstructed network gave insight into cellular machineries such as TOR, MAPK and sphingolipid-mediated signaling cascades as the mostly responsive cellular pathways in the methionine-restricted cases with Sch9p (functional orthologue of mammalian S6 kinase) being placed at the intersection of these signaling routes.</p>", 
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    "keywords": [
      "Methionine restriction", 
      "cancer", 
      "transcriptomics", 
      "systems biology", 
      "network analysis"
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    "publication_date": "2023-05-23", 
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      "subtype": "article", 
      "title": "Dergi makalesi", 
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    "science_branches": [
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik", 
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik > Genetik Bozukluklar\u0131n Molek\u00fcler Biyolojisi", 
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik > Kanser Molek\u00fcler Biyolojisi"
    ], 
    "title": "Methionine restriction and cancer treatment: a systems biology study of yeast to investigate the possible key players"
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